Changeagent's and your insights are brilliantly on target for us here.
Confusion/chaos is the attempted psycho-esoteric method and goal of the cabal. However we don’t have to be lured into trying to process every changing detail in this barrage of conflicting inputs. It's meant to disable us. They want people to drown in it.
Amid this engineered ‘climate change’ of weaponized confusion (via pervasive lies and managed shifting narratives everywhere), we can hold the line by not following every Shiny Object (as Gen. Flynn put it), but by practicing something rare but devastating to their agenda: Reserving Judgement.
We don't need to engage and go down every new rabbit hole, but sustain our mental focus and discernment. And help where we can, especially locally. Also provide air support = prayer support, peaceful reason, thoughtfulness, etc. Because we do CARE very much.
'They' consider the mass of humanity to be 'astrally polarized', e.g. to be driven (like cattle) primarily by our basic emotions. That is where they underestimate humanity's potential, and the actual 'image of God' as our core truth.
‘Digital soldiers’ especially should strive to maintain cool-headed focus, as this latest kind of Information Warfare swirls around us and indeed, is intentionally directed at those who attempt to understand exactly what they are doing.
But it’s eminently ok to simply ‘not know’ the answers, but to note/retain salient patterns, events and information for possible research and future clarification [or not] - while dispassionately Reserving Judgement. Watchdogs should not pounce on every steak (poisoned or not) invaders may toss at them.
DIGITAL WARRIORS 101
- In Physiological Psychology, taking in multiple diverging sensory inputs can throw the brain into alpha rhythm, i.e. a light but highly suggestible trance state. This can easily disarm rational thinking by ‘confusing’ the brain via the senses.
That’s why ’News’ outlets adopted a screen format with moving visuals plus sound, while at the same time, unrelated written material and icons popping in & out continuously scroll across the bottom, sides and/or top of the frame. It’s meant to confuse the mind by over-challenging it to try and synthesize all the varying inputs.
Simply gazing at a meadow, e.g. doesn’t confuse the mind like that. The stimulus is rich and deep vs. on the surface and conflicted; so it instead allows higher insight and genius intuitions to surface. The mind is aligned/congruent, coherent and open to truth vs. suggestion.
But trying to wrestle with crazy news and online cycles of multiple, ever-shifting sinister/(comical?) balloons, traumatic disasters, theories and morphing villains, in an engineered climate of threatening ‘war and rumors of war’, crashes, food shortages - this is quintessential psyops, with our mental function and morale as the targeted battlespace.
- A second aspect of this is the enemy deliberately sowing confusion about just WHO AND WHAT TO TRUST. This leaves people radically disempowered and looking for ‘answers’ and emotional refuge to emerge from a ‘Trusted Truth Leader’ /oracle.
To do that you have to sow confusion, uncertainty and doubt:
(Setting aside what you may make of his other work/information), Dr. Steven Greer has written a superb paper (in 2002) on the cabal's use of DDT in propaganda - ’Decoy, Distract and Trash’.
https://siriusdisclosure.com/cseti-papers/ddt
DDT: Decoy, Distract and Trash – Dr. Steven Greer (2002)
‘A former high official at the NSA (National Security Agency) told me [Greer] about a protocol informally dubbed DDT – that old poisonous chemical long-banned in much of the world. In this application, it stands for Decoy, Distract and Trash – which is what sophisticated intelligence operatives use to set up some person or group, take them off the trail of something real and important, and **trash the person or the subject”. [‘Trashing’ can include direct attacks such as false accusations/rumors; twisting narratives and projection (‘’Russia, Russia’, J6’, ); directing cancel culture/censorship; Pelosi’s duper’s glee about the ‘wrap-around smear’ technique; + tntm.]
B-but, but Everybody [at GreatAwakening, Democratic Underground, Fox and Friends…] Knows that…….’ Or is it more like, maybe assume we all probably actually know next to nothing? Q pointed us at research, but stepped back from being the Voice we credulously follow.
THEREFORE, personally I’m still ‘Reserving Judgement’ about many innuendoes that have been inserted into our collective I have NO IDEA if Hollywood Star A or B ‘eats babies’ or is a pedo, e.g. by ONLY what has been circulated on the Internet.
Some may be ultimate evildoers, but Reserving Judgement’ could also include a sort of presumption or hope of innocence for our fellow humans. The cabal’s ever emerging ‘Identified Villains’ may/may not not be actual villains, but scapegoats or decoys. ‘They want us divided.’ - Q.
SOME indescribably horrible accusations MAY possibly be part of the 5th-Generation Warfare being propagated on us. Near the beginning of Q, for instance, articles started circulating with innuendoes about Trump and Epstein related issues. But they withdrew those, and seemingly went with ‘Russia’ instead.
So let’s hold the line also by not engaging/'reacting' too emotionally with DDT, and by intentionally cultivating our powers of peaceful, rational thinking and actual discernment.
And ironically (+ being another pseudo-magical/psychological projection attempt?), they are the ones behaving like parasites.
Nah, those aren't evil creepy alien space vehicles. They're simply the latest species of crickets (for us to eat of course, vs. the 'How to Best Serve Mankind' scenario).
Come to think of it, crickets also look kind of.... 'baffomettish'(?)
Lots of nicely chosen, high-creep-factor subliminals [cf. also 'Winston's greatest fear' from 1984] cropping up everywhere, to stir up humankind's fear of insectoid shapes.
Bon appétit!
Are they doing Comms, like what's been alleged regarding Melania's dresses?
Hormones introduced into the food chain that were used e.g., to plump up chickens and other animals (to yield more profitable #s of meat per chicken), also act to fatten humans.
The enormously fat grocery store chicken legs, thighs, etc. seen today, did not used to be typical.
... With greedy Big Pharma/Big Medicine also lying in wait to profit off of the increase in degenerative diseases.
'This kind comes out only by prayer and fasting.' ~ Jesus
Humans are beings both spirit and material/biological. Fasting is a kind of (humble) mastery or spiritual warfare, to intentionally put spirit 'in the driver's seat'. And it's also one powerful form of 'voting' that cannot be tampered with.
There are many other effective kinds of fasting: on bread-and-water (many worldwide fast on Tuesdays and Thursdays - the days Jesus was betrayed and killed - to ask conversion for the world); the total absence of food (for set hours or days);
minimal plain food (abstain from delicious or savory food - no salt, spices, sweets; drink watered-down coffee, etc.; also as you have said, there are minimalizations/fasts from online activities, entertainment, etc. + doing acts of goodness and mercy, giving alms to help people, etc.
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There are extended complete fasts, as when Jesus in the desert ate nothing for 40 days.
Secular fasting has been done also, such as by Gandhi, to increase the people's 'soul-force' in support of a just cause - such as the Great Awakening. (That's why political 'authorities' sometimes try to stop fasting by force feeding. But the moral/spiritual intent remains.)
Or for a city/nation-state, this 3-day severe/completely successful version is in Jonah 3:1-10:
Ninevah repents:
3 Now the word of the Lord came to Jonah the second time, saying, 2 “Arise, go to Nineveh, the great city, and proclaim to it the proclamation which I am going to tell you.”
So Jonah got up and went to Nineveh according to the word of the Lord. Now Nineveh was [an exceedingly large city, a three days’ walk. 4 Then Jonah began to go through the city one day’s walk; and he cried out and said, “Forty more days, and Nineveh will be overthrown.”
5 Then the people of Nineveh believed in God; and they called a fast and put on sackcloth, from the greatest to the least of them.
6 When the word reached the king of Nineveh, he got up from his throne, removed his robe from himself, covered himself with sackcloth, and sat on the dust.
7 And he issued a proclamation, and it said, “In Nineveh by the decree of the king and his nobles: No person, animal, herd, or flock is to taste anything. They are not to eat, or drink water.
8 But every person and animal must be covered with sackcloth; and people are to call on God vehemently, and they are to turn, each one from his evil way, and from the violence which is in their hands.
9 Who knows, God may turn and relent, and turn from His burning anger so that we will not perish.”
10 When God saw their deeds, that they turned from their evil way, then God relented of the disaster which He had declared He would bring on them. So He did not do it.
Yoda was wrong. There is 'Try' - and it's also heroic and powerful.
:)
Once they were each an innocent-hearted baby and child.
But a prowling lion roams about, especially seeking innocent victims to devour. And the evils of one anothers' actions help facilitate that.
The hideous power of evil found an inroad to get ahold of each of them. Human nature is weakened, and we fall, and get pulled down even deeper.
Which is an immeasurable TRAGEDY to happen to that baby and child.
If they were a family member, friend, neighbor e.g. - we'd urgently and wholeheartedly pray for them, and long them to be fully rescued, forgiven, restored.
God is described as having 'so loved humanity/the world', and expressing that 'It is mercy I desire.'
So if it's possible - keep us all safe from temptation. And deliver us all from evil. All those in most need of mercy - yes all victims, but also the truly pitiable perpetrators.
For me (and so many watching the film Star Wars. e.g.), it felt so spiritually and emotionally right and perfect when Darth Vader turned good again.
And ill-eagle too.
umm............... no.
Sounds like some random, vaguely theological, new age-y sounding personal belief system.
And is this supposed to rally Q people?
doesn't sound like Q at all.
The new ones just don't.
Including possibly something like, Rig for Red, Rigged for the Storm, all Bread Baker / Anons on deck(?)
https://greatawakening.win/p/15K6qFMto0/q-3879--baker-already-noted-qpri/c
Q 3879 - Baker Already Noted Q..Primary purpose of referencing ‘Twitter’ accounts_...-- Elon today on Twitter- “Fresh baked bread”...(For those who aren’t aware the Anons posts to the boards where Q posted are called “Bread”, Anons are called bakers)
Hmm, surely by ~coincidence, the word Baker has also cropped up in other news stories this week:
https://greatawakening.win/p/15K6lfW1rc/rumours-are-that-jim-baker-comey/c
Rumours are that JIM BAKER (Comey's FISAgate flunky) that has been Deputy General Counsel and VP at Twitter has been let go! NOTABLE! - The Great Awakening - Where We Go Qne, We Go All! >
https://media.patriots.win/post/KFhlb0JhQJ3g.jpeg (Paul Sperry - Oct. 28, 2022)
..........
https://greatawakening.win/p/15K6cEmLqb/california-baker-who-refused-to- California Baker Who Refused To Make Gay Wedding Cake Wins Huge Court Victory - The Great Awakening - Where We Go Qne, We Go All!
https://redstate.com/kiradavis/2022/10/23/california-baker-who-refused-to-make-gay-wedding-cake-wins-huge-court-victory-n647643 (Kira Davis) - Oct. 21, 2022
'Ironic that “a law intended to protect individuals from religious discrimination was used to discriminate against Cathy [note also re: Baker, defendant 'Miller'] for her religious beliefs.” - (her lawyer Paul Jonna, Thomas More Society)
Wow, simply stated but a very profound philosophical topic. :)
If paying attention, there is a definite resonance to encountering truth, as you say. But the contextual explanation for that resonance, the narrative framework surrounding it, could and does change. Or it can get redpilled, if you will.
My own mental understandings can and do shift and evolve or deepen; however the deeper core truths (heart, soul, love-based ethics) retain that joyous abiding sense of resonance.
To use a catholic example, John Paul II (in an essay 'Why So Many Religions') wrote of the 'Semina verbi' or 'Seeds of the Word' found within all religions, cultures, etc. Truth is their essence, even though these seeds may be enclosed within many differing forms.
It brings a dynamic tension to all our perspectives, where our individual minds seek 'best evidence truth', at the same time our hearts seek the truth of how it all relates in loving unity.
Like resonates with like, as our core human self resonates within a larger design of what is Good (as above, below) - unless we're somehow bound up so as not to be free to resonate). It's like the cognitive dissonance and emotional resistance that can keep people from just simply becoming red-pilled.
Coincidentally I was just reading about the 4 results of being a part of a 'fallen humanity' (whether you see that as 'fallen from' or 'evolving to' a higher way of being).
The 4 effects are: death (vs. immortality); suffering/striving/struggle (vs. 'effortlessness'); a tendency to be draw toward doing evil; and surprisingly - ignorance. So not knowing truth might be intrinsic to humanity at this stage of our being.
This idea was surprising to me, as I'm always looking for truth; however vast portions of the Earth do consider avidya, maya, agnosticism, etc. to be our normal state.
So it seems like optimally, yes we can powerfully recognize aspects of truth when we encounter them. But as to the intellectual/cultural frameworks, paradigms and narratives they may appear in - these may actually be false.
And advertisers, subversive psyops operators, etc. can try to intentionally manipulate and harm us by expertly co-mingling attractive, universally resonant images and truth with deliberate subtle disinfo; e.g., an example: no caring person wants a 'pandemic' to harm everyone. But that does not automatically mean to just run out and get a vaccine! Happy singing and dancing nurses, civic minded vaccine ads, etc. are in effect, 'poison pills'.
And that's not to forget, no one wants obscure 'weapons of mass destruction!' to get them. So let's all keep America safe by invading the cabal's next target nation.
Yes there are myriad 'psyops' and perspectives, as you say a treasure hunt. But there are some skillfully created narratives that may deliberately mean us harm (loss of freedom, death, monopoly, etc.) All humans resonate to a beautiful environment - but we also require the discernment not to fall prey to the cabal's consummately evil Climate Change hoax.
They use herd techniques. So they may pervert Semina Dei, the resonant truths (carrots) with laying the groundwork for coercive measures (sticks). Caring + scaring.
Americans who love their land and want the best, were somehow manipulated into mindlessly cheering 'USA! USA!' to support invading Iraq on behalf of the Bush/Cheney agenda. This perversion of loving goodwill did not resonate with truth and beauty.
So one main concern with (possible) UFO-related cabal psyops narratives, no matter how full of light and love and wonder their contents may be - is that they may be meant to drive behavior, i.e. draw people in and prepare our unsuspecting minds to go along with future coercive scenarios (an 'alien invasion' false flag, e.g.) we'd otherwise never accept.
Like a good physician, we may need to employ a higher 'index of suspicion' as part of Information Warfare. UFO-related material is psychospiritual dynamite, and desirable for cabal agendas, embodying potential narrative control of humanity's overall worldview and even key religious/spiritual aspects.
So maybe a lot if not all of the UFO-related narratives 'out there' in public, may benefit by being researched a wee tad bit more deeply as befits anons.
Agree, faith 'even the size of a mustard seed' is a powerful potential, if unfallen humans were 'made in the image and likeness of God' we may well also be co-creators in as yet largely unknown ways. Many faiths, esoteric and science also hints at this.
...
(But fwiw - as to a wingmakers aspect, I read in the late '90s that their material should be viewed as more of a control-the-narrative psyop or speculative theory, rather than held as a 100% true information source. Many 'ufo experiencers' were also being manipulated back then, presumably by cabal factions.
That's also way back when the 'climate change' psyop - being seeded into the New Age community by no less than 'wise Native elders' supposedly directly in tune with Great Spirit and benificent Yoda-like ETs' - was being called 'Earth Changes'...)
Superb, thank you.
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Actually yes, I absolutely care what (so-called) normies think of Q.
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More to the point re: Q, I care that anons don't provide ds media any juicy ammunition with which to craft false narratives that compromise and muddy Q's efforts to wake everyone else up.
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All normal (expertly manipulated) victims of MSM fell hard for 9-11 propaganda, for 'covid', for J-6 as a maga 'insurrection'.
4.Our normie friends and neighbors are still gullible until fully red-pilled, and that includes their realizing how deeply compromised the entire UFO issue already is.
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Ironically, that realization works like a 'vaccination' against falling for the long-planned (according to ds insider von Braun) evil alien/UFO false flag. Everyone needs to maintain their cool and operational awareness in this and any other 'information warfare' arena.
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Intriguing as the question of extraterrestrial intelligence totally is, the Q community embracing the UFO rabbit hole (with its many disinfo false trails and competing factions) could be a huge potential vulnerability for anons and the maga/mega process.
Of course, Jordan Sather (whose writings I often like) is also an alumnus of James Gilliland's Eceti Ranch, which introduces some inescapably problematical aspects to this whole ET/space subject. Not to mention that merely being from a military official these days, does not guarantee Truth is being presented to us.
Enter the Lionsgate.
The question of Life elsewhere in the cosmos is one of THE most hot-button topics in existence, being both quasi-religious and powerfully archetypal. Whoever manages to mold and control that narrative could wield immense power. Just look what damage they wreaked with 'covid', just a supposed Earth based virus.
So the cabal has been covertly trying to wrest control of this subject for generations. For a crude mid-20th century example, just look at the faked 'alien abduction'/mk Betty and Barney Hill psyop of 1961 (cf. 'The Interrupted Journey, by John G. Fuller).
It looks really hokey and shady now. Imagine the 'Zeta Reticulans' helpfully providing a 2-D star map with their solar system in the background (as seen from Earth, no less) for Barney to conveniently glimpse!
In his last years, Wernher von Braun repeatedly warned of a planned 'False Flag from Outer Space'. To prep the masses for this, subliminal fears of 'evil demonic aliens' had to be stoked in every nefarious way, to plausibly trot out these ETs as the Enemy Baddies for this ultimate false flag (er, or was that those Ultra-Maga Deplorables? We need a scorecard.)
So we need to come together as One World to defeat them!!!!!!!! And eat our bugs (before their Bugs/Reptilians/Soulless Greys eat us!)
So what is problematical about Eceti is that whenever people of good will gather publicly to 'contact extraterrestrial life' - they may also comprise an ideal Petrie dish situation for weaponised psychotronic (and mk-ultra type) experimentation and manipulation.
'Ooooh, look at that highly evolved Rainbow ship, hovering over us! Full of goodness & light Pleadian blondes! I read about them online!' But as Freud might say, sometimes a cigar-shaped space ship is just a cigar(?:)
Anyway, that's not to discount whatever valid experiences there may be.
However the bottom line seems to be to proceed with caution around all things ET. We'd probably do well to assume there's been tons of misinformation deliberately mingled into this subject, and over our entire lifetimes.
Also with 'QAnon' becoming a media target, any ET issues could be used to discredit and negatively project certain irrational belief systems onto 'Q/Maga Nazis'.
So we should optimally keep our Q comms discussions and research separate and clear of entanglement with all the various/complex alien theories and narratives circulating.
https://exonews.org/vice-news-claims-ufo-qanon-connection-is-disinformation
Vice News claims UFO & QAnon Connection is Disinformation
Put into its actual context, her understanding was based in how St. Paul and all the early Christians and martyrs down throughout history (i.e. 'a great cloud of witnesses'), viewed the nobility of offering their own sufferings to God out of love, 'as imitators of Christ'.
And for balance, bear in mind that at the very same time - they were also going around profusely healing and delivering and raising from the dead.
It seems more likely (other than 'meanness') that Mother Teresa felt she was offering the poorest of the poor the absolute dignity of sharing in Christ's passion, (in cases where they also didn't exactly have access to all the wonderful 21st century Korporate Medi$ine we fortunately do...)
“Now I rejoice in my sufferings for your sake, and in my flesh I complete what is lacking in Christ’s afflictions for the sake of his body, that is, the church ... to make the word of God fully known, the mystery hidden for ages and generations but now made manifest to his saints.” (Colossians 1:24-26)
https://catholicstand.com/complete-suffering-of-christ
People may not all share the same spiritual beliefs, but that doesn't mean to impute evil to others perspectives either. Understanding is a gift of the Holy Spirit:
https://catholicstraightanswers.com/gifts-understanding-wisdom
St. Paul captured well this gift of wisdom: “What we utter is God’s wisdom: a mysterious, a hidden wisdom. God planned it before all ages for our glory. …Yet God has revealed this wisdom to us through the Spirit. …
The Spirit we have received is not the world’s spirit but God’s Spirit, helping us to recognize the gifts He has given us. We speak of these, not in words of human wisdom but in words taught by the Spirit, thus interpreting spiritual things in spiritual terms.
The natural man does not accept what is taught by the spirit of God. For him, that is absurdity. He cannot come to know such teaching because it must be appraised in a spiritual way. The spiritual man, on the other hand, can appraise everything. We have the mind of Christ” (I Cor 2:6ff).
'They (our enemies) want us divided.'. ~ Q
However, if slander or insinuations or calumny narratives against public figures or groups we are iffy about, are circulated online (or in MSM)?
Well then, that's different - all those automatically must be true.
You know, like all that stuff they have on Trump and those deplorable enemy Magas and 'QAnons'!
By no means reserve judgement or anything.
Thanks. Totally off topic, yet.......... strangely refreshing.
It's the 1st thing in days that's taken my mind off worrying about the usual/destructive 'world events'.
(The better to carry on doing the 'restorations' we're all about accomplishing here... :)
Yes your compassionate insight is true, however 'they'/the one-world would-be despots who are intentionally driving this mass artificial influx of people over western society's borders, are absolutely counting on our basic decency and compassion to get their Trojan Horse inside all our gates.
Most citizens -already living here- do not get their basic food, water and shelter needs met either. Despite benefits for some - we have huge numbers of homeless Americans, plus older people secretly eating catfood, etc. (if they can even afford that now).
Our already economically decimated, indebted and struggling people here, can't also support the 3rd world (unless perhaps these working poor have an extra home or two on Martha's Vineyard?) Nor can they afford to buy 'Survival Food' to tide their families over if needed, or buy gold and silver.
These of our citizens (even the border crossers, ultimately) are largely defenseless and vulnerable to those globalist fascists whose intentions are merciless. A philosophy + compassion to build a truly good world that Makes Every Person's Home Nation Great is called for (contrasted w/ the cabal's war/exploitatin model).
This is all designed to further destabilize the west, and thus claw to themselves more fascistic Kontrol, by overwhelming and destroying our working poor and middle class here. Ultimately they mean to reduce what was once a thriving middle class to basically serfdom. The Marxist playbook.
A brilliant insight ... as via the Mind-Body connection and consciousness of both aspects, the Mind and Body can and do communicate (interchange back and forth) with one another.
Guided Imagery/psychosynthesis researchers have described the Body's level of communication as about that of a 5-year old child's - basic and literal.
(Of course this is just some public domain info to research further - not specifically ‘medical advice’ :)
However it’s very hopeful research, and quite a few (exceptional) health care practitioners (orthomolecular & naturopathic physicians in particular) know of and use it widely.
……….
Vitamin E in its naturally polarized ‘dextro-' form (natural right-polarized d-alpha tocopherol - vs. dl or the artificial dextro/levo synthetic form) may provide an especially valuable healing environment for vascular and other tissues.
(Also rarely, a few people may not take to Vitamin E as well as others, due to each human’s ‘Biochemical Individuality’ (also important in v- issues!). So staying mindful, and if desired checking w/ your health care people, is nice too.)
Also this Vitamin E delivery form, d-α-tocopheryl polyethylene glycol-succinate (i.e. combined with a particular delivery system that can maximize effects) has been found to be particularly promising for many (!!) potential clinical applications.
Drs. Wilfrid and Evan Shute did extensive research on the myriad range of incredible clinical healing effects of natural d-alpha tocopherol Vitamin E in the 1940’s & on. They were genius brothers, medical pioneers and true healers, who had their own independent lab in Canada; therefore the usual pharma special interests couldn’t fully suppress their research.
If you read Vitamin E labels closely, you can find the natural d-alpha tocopherol form in drugstores. Personally I like the generous 670 mg / 1000 IU softgels. These soft gels of Vitamin E are also effective when applied externally to protect skin and facilitate healing from burns, such as sunburn, etc.
A couple of examples below, can be a starting point for further research:
This first suggestive animal study (involving retinal ischemia), is actually from food production science:
https://www.researchgate.net/publication/7246801_Protective_Effects_of_Vitamin_E_Forms_Alpha-tocopherol_Gamma-tocopherol_and_d-alpha-tocopherol_Polyethylene_Glycol_1000_Succinate_on_Retinal_Edema_During_Ischemia-reperfusion_Injury_in_the_Guinea_Pig_ Protective Effects of Vitamin E Forms (Alpha-tocopherol, Gamma-tocopherol and d-alpha-tocopherol Polyethylene Glycol 1000 Succinate) on Retinal Edema During Ischemia–reperfusion Injury in the Guinea Pig Retina _ Request PDF
October 2004 International Ophthalmology 25(5-6):283-9
‘The purpose of this study is to provide evidence that free radical damage is a component of retinal ischemia-reperfusion (I/R) injury, and to determine whether alpha-tocopherol, gamma-tocopherol and d-alpha-tocopherol polyethylene glycol 1000 succinate (TPGS) can protect the retina from this injury.
[They induced retinal ischemia in lab guinea pigs ………. All the three substances showed statistically significant protection against the formation of retinal edema during ischemia-reperfusion injury.]
The results from these experiments indicate that vitamin E forms have protective effects on the retina during retinal ischemia-reperfusion injury, but, the effects of alpha-tocopherol and TPGS appear to be much greater than that of gamma-tocopherol.
……….
*Journal of Drug Delivery on TPGS:
https://www.tandfonline.com/doi/full/10.1080/10717544.2017.1406561 Full article_ Recent developments in d-α-tocopheryl polyethylene glycol-succinate-based nanomedicine for cancer therapy
Songwei Tan,Chenming Zou,Wei Zhang,Mingxing Yin,Xueqin Gao &Qing Tang Pages 1831-1842 | Received 28 Sep 2017, Accepted 14 Nov 2017, Published online: 28 Nov 2017
‘As an FDA-approved biocompatible drug excipient, d-α-tocopheryl polyethylene glycol succinate (TPGS) has been widely applied in drug delivery system (DDS). Along with in-depth analyses of TPGS-based DDS,increasingly attractive results have revealed that TPGS is able to act not only as a simple drug carrier but also as an assistant molecule with various bio-functions to improve anticancer efficacy.
In this review, recent advances in TPGS-based DDS are summarized. TPGS can inhibit P-glycoprotein, enhance drug absorption, induce mitochondrial-associated apoptosis or other apoptotic pathways, promote drug penetration and tumor accumulation, and even inhibit tumor metastasis. As a result, many formulations, by using original TPGS, TPGS-drug conjugates or TPGS copolymers, were prepared, and as expected, an enhanced therapeutic effect was achieved…’
45 and 47 also resonate with '9-11'.