The levels of HCQ in these patients (serum levels) was likely much higher than these numbers would suggest.
Levels of toxicity are based upon research conducted with healthy subjects with fully functional detoxifying systems (liver and kidneys). This is why kidney and liver function must be monitored with many medications.
These patients were very sick, and their detoxifying systems were surely overtaxed and impaired. As a result, serum levels would be much higher than normal and the resultant toxicity would be considerably higher.
Physicians and pharmacists know about a thousand ways to kill a person (and they do a lot more than people know). These Evil Fucks knew exactly what they were doing.
The danger of giving too much HCQ in a loading dose is because of its pharmacokinetic profile. It has a plasma half life of 123 days. This means that the drug is incredibly slow to clear the body. Anyone setting a dose of this drug should know that however. The regimen that was recommended just kept packing the system with more (unneeded) drug. Should be up on charges. But this dose SHOULD have been noticed by the many Docs and Pharmacists dispensing it. Crazy bad practice. Seems unbelievable.
I was not aware that its serum half life was that long. I found it listed as 1300 hours. Loading dose seems even crazier now. None of those trial participants (victims) stood a chance. Honestly, I can't see any of this being anything other than deliberate. Even if the drug were unfamiliar to them, every clinician and pharmacist I know would be doubly careful with something they don't use often. TY
The levels of HCQ in these patients (serum levels) was likely much higher than these numbers would suggest.
Levels of toxicity are based upon research conducted with healthy subjects with fully functional detoxifying systems (liver and kidneys). This is why kidney and liver function must be monitored with many medications.
These patients were very sick, and their detoxifying systems were surely overtaxed and impaired. As a result, serum levels would be much higher than normal and the resultant toxicity would be considerably higher.
Physicians and pharmacists know about a thousand ways to kill a person (and they do a lot more than people know). These Evil Fucks knew exactly what they were doing.
The danger of giving too much HCQ in a loading dose is because of its pharmacokinetic profile. It has a plasma half life of 123 days. This means that the drug is incredibly slow to clear the body. Anyone setting a dose of this drug should know that however. The regimen that was recommended just kept packing the system with more (unneeded) drug. Should be up on charges. But this dose SHOULD have been noticed by the many Docs and Pharmacists dispensing it. Crazy bad practice. Seems unbelievable.
I was not aware that its serum half life was that long. I found it listed as 1300 hours. Loading dose seems even crazier now. None of those trial participants (victims) stood a chance. Honestly, I can't see any of this being anything other than deliberate. Even if the drug were unfamiliar to them, every clinician and pharmacist I know would be doubly careful with something they don't use often. TY