The reagent in some kits may contain other constituents, including Triton-X, inorganic phosphate, and Pro-Clin 300. The latter ingredients are unlikely to cause human toxicity if small amounts are ingested, but they may cause allergic reactions or local irritation after ocular or dermal exposure. However, sodium azide is well-known for its ability to cause harmful effects in humans, especially after oral exposures and potentially including the ingestion of reagent solution. Additionally, since the reagent solution packaging may include ampules that allow for application of drops of solution to the test device, inadvertent ocular sodium azide exposures can occur if the ampule is mistaken for an eyedropper.

Kits that have reagent fluid with higher sodium azide concentrations (greater than or equal to 0.09%), including the BD Veritor™ and Celltrion DiaTrust™ testing systems, contain approximately 0.3 mg of sodium azide [10,11]. Ingestions of this magnitude may result in hypotension, decreased end-organ perfusion, and syncope. Children may experience serious adverse events after exploratory oral exposures to minimal amounts of the reagent solutions due to their smaller body size and should be monitored closely for hypotension or other sequelae after ingestion of even minute quantities of reagent fluids