Let me be more specific. These mRNA immunotherapies deliver mRNA into the cytosol of a cell. The mRNA is then translated into a protein. At no time does the mRNA make it into the nucleus and interact with the DNA. Its nearly impossible for it to make it into the nucleus, and nearly impossible for it to be reverse transcribed onto the DNA. Even if it somehow managed those two separate nearly impossible tasks, it would be nearly impossible for it to be later transcribed from DNA into mRNA as it would be very unlikely to have the transcription sequences upstream to get the machinery on there to make that happen. Even if that happened it would extremely unlikely that it would be in the proper reading frame and have a termination sequence at the right place.
In other words, the odds of this happening in a single cell, using this particular technology is 4 x N, where N = nearly impossible. And that's just for one cell. To happen in multiple cells = M x 4 x N where M = multiple cells.
It would be ludicrous to use this as a "gene therapy". It's efficacy would be on the order of
0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001
I'm only giving it that much credit because I got bored writing zeros.
Let me be more specific. These mRNA immunotherapies deliver mRNA into the cytosol of a cell. The mRNA is then translated into a protein. At no time does the mRNA make it into the nucleus and interact with the DNA. Its nearly impossible for it do make it into the nucleus, and nearly impossible for it to be reverse transcribed onto the DNA. Even if it somehow managed those two separate nearly impossible tasks, it would be nearly impossible for it to be later transcribed from DNA into mRNA as it would be very unlikely to have the transcription sequences upstream to get the machinery on there to make that happen. Even if that happened it would extremely unlikely that it would be in the proper reading frame and have a termination sequence at the right place.
In other words, the odds of this happening in a single cell, using this particular technology is 4 x N, where N = nearly impossible. And that's just for one cell. To happen in multiple cells = M x 4 x N where M = multiple cells.
It would be ludicrous to use this as a "gene therapy". It's efficacy would be on the order of
0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001
I'm only giving it that much credit because I got bored writing zeros.
Let me be more specific. These mRNA immunotherapies deliver mRNA into the cytosol of a cell. The mRNA is then translated into a protein. At no time does the mRNA make it into the nucleus and interact with the DNA. Its nearly impossible for it do make it into the nucleus, and nearly impossible for it to be reverse transcribed onto the DNA. Even if it somehow managed those two separate nearly impossible tasks, it would be nearly impossible for it to be later transcribed from DNA into mRNA as it would be very unlikely to have the transcription sequences upstream to get the machinery on there to make that happen. Even if that happened it would extremely unlikely that it would be in the proper reading frame and have a termination sequence at the right place.
In other words, the odds of this happening in a single cell, using this particular technology is 4 x N, where N = nearly impossible. And that's just for one cell. To happen in multiple cells = M x 4 x N where M = multiple cells.
It would be ludicrous to use this as a "gene therapy". It's efficacy would be on the order of
0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001
I'm only giving it that much credit because I got bored writing zeros.
Let me be more specific. These mRNA immunotherapies deliver mRNA into the cytosol of a cell. The mRNA is then translated into a protein. At no time does the mRNA make it into the nucleus and interact with the DNA. Its nearly impossible for it do make it into the nucleus, and nearly impossible for it to be reverse transcribed onto the DNA. Even if it somehow managed those two separate nearly impossible tasks, it would nearly be impossible for it to be later transcribed from DNA into mRNA as it would be very unlikely to have the transcription sequences upstream to get the machinery on there to make that happen. Even if that happened it would extremely unlikely that it would be in the proper reading frame and have a termination sequence at the right place.
In other words, the odds of this happening in a single cell, using this particular technology is 4 x N, where N = nearly impossible. And that's just for one cell. To happen in multiple cells = M x 4 x N where M = multiple cells.
It would be ludicrous to use this as a "gene therapy". It's efficacy would be on the order of
0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001
I'm only giving it that much credit because I got bored writing zeros.
Let me be more specific. These mRNA immunotherapies deliver mRNA into the cytosol of a cell. The mRNA is then translated into a protein. At no time does the mRNA make it into the nucleus and interact with the DNA. Its nearly impossible for it do make it into the nucleus, and nearly impossible for it to be reverse transcribed onto the DNA. Even if it somehow managed those two separate nearly impossible tasks, it would nearly impossible for it to be later transcribed from DNA into mRNA as it would be very unlikely to have the transcription sequences upstream to get the machinery on there to make that happen. Even if that happened it would extremely unlikely that it would be in the proper reading frame and have a termination sequence at the right place.
In other words, the odds of this happening in a single cell, using this particular technology is 4 x N, where N = nearly impossible. And that's just for one cell. To happen in multiple cells = M x 4 x N where M = multiple cells.
It would be ludicrous to use this as a "gene therapy". It's efficacy would be on the order of
0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001
I'm only giving it that much credit because I got bored writing zeros.