On whether ADE is a concern - your characterization is correct but the fact that it hasn't showed up yet is not indicative of it not being a problem. It's unclear how long it might take to show up.
The way this shot seems to work it causes the host's system to learn a large number of different types of antibodies. The majority of the unique antibody types are non-neutralizing (meaning that they bind to the antigen but do not stop it from working and replicating). (see https://www.medrxiv.org/content/10.1101/2021.03.07.21253098v2 )
The reason the shots appear to work initially is that the titers of the neutralizing antibodies are higher, even though there are more unique antibody types that are non-neutralizing.
Trouble is, the titers wane over time, not necessarily in a coordinated fashion. This could allow the balance to shift over time, and if the balance shifts to the non-neutralizing, and if a variant happens to activate more of those and exploit them, you have a big problem.
The other concern I have personally about this (and I don't think I have seen this concern voiced elsewhere so maybe it's bullshit) is that this mRNA technique generates a predictable set of antibodies, and generates antibodies that would not be, (or only rarely would be) created by a natural infection or even a more traditional vaccine that acts more like an attenuated form of the real infection. This means the "vax" population could have a predictable response to a new (engineered?) antigen that keys off those unnatural antibodies that are only present in the vax population.
That is, the vaccine rollout produces a vulnerability unique to that population, that could be exploited as if it were a binary (2 part) bio-weapon, one that primes and one that kills. It wouldn't even require collusion between the vax merchant and the person who wants to commit genocide, because it's easy to know precisely what antibodies these people will have. It's basically like a monoculture type vulnerability - the vaccine produces less diversity than the natural infection, and produces them predictably. As I understand it, china delivered the spike protein and suggested the idea of using it to pfizer et al... and they also banning use of the mRNA vax. At least that is what I recall. That's not a great sign if we really are at war with China or if things heat up.
Another thing that is an interesting signal is in the reaction to delta variant among UK vaccinated people.
see table 4 in particular.
If you compute the Case Fatality Rate for unvaccinated, partly, and fully vaccinated, you get unvax: 0.10%, partly: .08%, fully: 0.64%. Note the CFR went up with fully vax people by 6x!
If you work out the population sizes of unvax, part and full vax, it turns out that the deaths overall in the population (which could be a measure of IFR assuming the infections are distributed evenly among the groups) are about 32% lower after the first shot, and 40% lower than unvax after the second.
This tells you a few things:
- it doesn't really work on delta
- there is negligible benefit to the second shot in terms of death rate.
- the second shot does reduce the CASE rate a lot, which leads to much higher CFR.
Here's my concern: does this mean there are 2 separate effects, one reducing cases (non-mild infections in some sense) and another one that is INCREASING odds of death given non-mild infection? If so and case prevention fades while the other does not, could be very bad.
All in all, I think the odds of a naturally occurring ADE situation in the next 5 years are fairly high. How deadly it ends up being, is harder to say. If someone wants to engineer depopulation, that could be a lot more deadly than a natural ADE. I think the Pharma plan is to sell boosters ad infinitum to keep those neutralizing antibodies up and provide updates for new variants. Of course it also destroys your immune system and every booster is russian roulette but it's going to be very profitable. It could be that people unrelated to Pharma have another plan.
I can't really imagine how you can really undo what this shot does, if the antibodies created are bad, you're basically permanently fucked.
On whether ADE is a concern - your characterization is correct but the fact that it hasn't showed up yet is not indicative of it not being a problem. It's unclear how long it might take to show up.
The way this shot seems to work it causes the host's system to learn a large number of different types of antibodies. The majority of the unique antibody types are non-neutralizing (meaning that they bind to the antigen but do not stop it from working and replicating). (see https://www.medrxiv.org/content/10.1101/2021.03.07.21253098v2 )
The reason the shots appear to work initially is that the titers of the neutralizing antibodies are higher, even though there are more unique antibody types that are non-neutralizing.
Trouble is, the titers wane over time, not necessarily in a coordinated fashion. This could allow the balance to shift over time, and if the balance shifts to the non-neutralizing, and if a variant happens to activate more of those and exploit them, you have a big problem.
The other concern I have personally about this (and I don't think I have seen this concern voiced elsewhere so maybe it's bullshit) is that this mRNA technique generates a predictable set of antibodies, and generates antibodies that would not be, (or only rarely would be) created by a natural infection. This means the "vax" population could have a predictable response to a new (engineered?) antigen that keys off those unnatural antibodies that are only present in the vax population.
That is, the vaccine rollout produces a vulnerability unique to that population, that could be exploited as if it were a binary (2 part) bio-weapon, one that primes and one that kills. It wouldn't even require collusion between the vax merchant and the person who wants to commit genocide, because it's easy to know precisely what antibodies these people will have. It's basically like a monoculture type vulnerability - the vaccine produces less diversity than the natural infection, and produces them predictably. As I understand it, china delivered the spike protein and suggested the idea of using it to pfizer et al... and they also banning use of the mRNA vax. At least that is what I recall.
All in all, I think the odds of a naturally occurring ADE situation in the next 5 years are fairly high. If someone wants to engineer depopulation, that could be a lot more deadly than a natural ADE. I think the Pharma plan is to sell boosters ad infinitum to keep those neutralizing antibodies up and provide updates for new variants. Of course it also destroys your immune system and every booster is russian roulette but it's going to be very profitable. It could be that people unrelated to Pharma have another plan.
I can't really imagine how you can really undo what this shot does, if the antibodies created are bad, you're basically permanently fucked.