Here’s your study:
https://www.mdpi.com/1422-0067/20/4/896/htm
“Vitamin K1 is preferentially retained in the liver to assist carboxylation of clotting factors [53]. In contrast, vitamin K2, particularly long chain derivatives, are redistributed to the circulation and are available for extra-hepatic tissues such as bone and vasculature (Figure 2) [5,53].”
Vitamin K: Double Bonds beyond Coagulation Insights into Differences between Vitamin K1 and K2 in Health and Disease
“The existence of vitamin K has been known for over 80 years, namely via its essential role in coagulation. The discovery of different isoforms of vitamin K is beginning to elucidate a significant role of vitamin K outside of coagulation. Functions of K2 are proving to be beneficial with regard to CVD and bone metabolism. There is a growing body of evidence suggesting vitamin K2 is involved in multiple cellular processes, and might have a protective role in various organs throughout the human body (Figure 3). While vitamin K2 has improved outcomes in many clinical trials, the exact mechanism of action remains to be unraveled. “
Here’s your study:
https://www.mdpi.com/1422-0067/20/4/896/htm
Vitamin K: Double Bonds beyond Coagulation Insights into Differences between Vitamin K1 and K2 in Health and Disease
“The existence of vitamin K has been known for over 80 years, namely via its essential role in coagulation. The discovery of different isoforms of vitamin K is beginning to elucidate a significant role of vitamin K outside of coagulation. Functions of K2 are proving to be beneficial with regard to CVD and bone metabolism. There is a growing body of evidence suggesting vitamin K2 is involved in multiple cellular processes, and might have a protective role in various organs throughout the human body (Figure 3). While vitamin K2 has improved outcomes in many clinical trials, the exact mechanism of action remains to be unraveled. “
Here’s your study:
https://www.mdpi.com/1422-0067/20/4/896/htm
Vitamin K: Double Bonds beyond Coagulation Insights into Differences between Vitamin K1 and K2 in Health and Disease