I'm having a difficult time rectifying this statement. I believe they are the exact same vaccine.
According to the FDA release above, the COMIRNATY vaccine has the exact same ingredients, including the exact same mRNA strand (bnt162b2).
On page 7 (bottom) it lists the ingredients. Every ingredient is the same as the Pfizer vaccine, including the first one (mRNA).
SARS-CoV-2 spike glycoprotein mRNA (UNII: 5085ZFP6SJ)
Looking up UNII: 5085ZFP6SJ it says:
Preferred Substance Name:TOZINAMERAN
Looking up TOZINAMERAN it says:
Tozinameran (BNT162b2) Vaccine
They are the exact same molecule.
I am not seeing any indication that there is anything "misleading" here.
If you have further evidence that approving the BioNTech is not the same as approving the Pfizer, when they both co-developed this exact vaccine (with the exact same serial number), please let me know.
As for the CORMIRNATY having "optimized codons" thats just jargon. All of the vaccines have "optimized codons". That just means that they changed some of the nucleosides to increase half-life of the mRNA in the cytosol (allowing for longer "effectiveness") and/or changed some of the nucleosides for other reasons. The way RNA to Amino acid coding works, with many redundancies in the code, allows for many potential modifications in RNA for whatever reason, while producing the same exact protein.
The information presented suggests that both Pfizer and CORMIRNATY have the exact same "optimized codons", suggesting this is only evidence of their sameness, not evidence of something different.
As for what it says on page 14:
The repeat dose toxicity evaluations were conducted on COMIRNATY and a similar vaccine termed BNT162b2 (V8). COMIRNATY and BNT162b2 (V8) have identical amino acid sequences of the encoded antigens but COMIRNATY includes the presence of optimized codons to improve antigen expression.
I can't rectify that. Maybe whoever wrote it misunderstood, or maybe there is something more to be found, but by the serial number they appear to be the exact same.
I'm having a difficult time rectifying this statement. I believe they are the exact same vaccine.
According to the FDA release above, the COMIRNATY vaccine has the exact same ingredients, including the exact same mRNA strand (bnt162b2).
On page 7 (bottom) it lists the ingredients. Every ingredient is the same as the Pfizer vaccine, including the first one (mRNA).
SARS-CoV-2 spike glycoprotein mRNA (UNII: 5085ZFP6SJ)
Looking up UNII: 5085ZFP6SJ it says:
Preferred Substance Name:TOZINAMERAN
Looking up TOZINAMERAN it says:
Tozinameran (BNT162b2) Vaccine
They are the exact same molecule.
I am not seeing any indication that there is anything "misleading" here.
If you have further evidence that approving the BioNTech is not the same as approving the Pfizer, when they both co-developed this exact vaccine (with the exact same serial number), please let me know.
As for the CORMIRNATY having "optimized codons" thats just jargon. All of the vaccines have "optimized codons". That just means that they changed some of the nucleosides to increase half-life of the mRNA in the cytosol (allowing for longer "effectiveness") and/or changed some of the nucleosides for other reasons. The way RNA to Amino acid coding works, with many redundancies in the code, allows for many potential modifications in RNA for whatever reason, while producing the same exact protein.
The information presented suggests that both Pfizer and CORMIRNATY have the exact same "optimized codons", suggesting this is only evidence of their sameness, not evidence of something different.