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Reason: None provided.

Now that I'm going through the detail of your reply - I question if your a troll.

If you have questions ask them. Calling me a troll is an ad hominem attack designed specifically to discredit me without addressing an argument. Please do not do that again.

Several ingredients are redacted on page 7 so there's absolutely no way for you to check that the ingredients are the same

None of the ingredients are redacted. They are listed right there. For example:

[redacted] [4-hydroxybutyl)azanediyl)bis (hexane-6,1- diyl)bis(2-hexyldecanoate) (UNII: [redacted]

The ingredient is here. It is the exact same lipid as in Pfizers vaccine. Whatever is redacted is NOT the ingredient. In this case it looks like whatever name they gave it was redacted and the UNII was redacted. Why? I have no idea. They are easy to look up. The name is ALC-0315 as it shows on the link above. This list of ingredients of the Pfizer vaccine shows it. The second "redacted" ingredient can be found in the same way. They are the exact same molecules.

But don't forget about those optimized codons man.

As I explained, every single vaccine uses "optimized codons". Its just a term. The fact that they use rhetoric that suggests it is exclusive to COMIRNTY on page 14 suggests to me the person who wrote that section didn't understand what someone told them, because the Pfizer vaccine also has optimized codons, as I explained above.

The design of Pfizer/BioNTech and Moderna mRNA vaccines involves many different types of optimizations. Proper optimization of vaccine mRNA can reduce dosage required for each injection leading to more efficient immunization programs. The mRNA components of the vaccine need to have a 5′-UTR to load ribosomes efficiently onto the mRNA for translation initiation, optimized codon usage for efficient translation elongation, and optimal stop codon for efficient translation termination. Both 5′-UTR and the downstream 3′-UTR should be optimized for mRNA stability. The replacement of uridine by N1-methylpseudourinine (Ψ) complicates some of these optimization processes because Ψ is more versatile in wobbling than U. Different optimizations can conflict with each other, and compromises would need to be made. I highlight the similarities and differences between Pfizer/BioNTech and Moderna mRNA vaccines and discuss the advantage and disadvantage of each to facilitate future vaccine improvement. In particular, I point out a few optimizations in the design of the two mRNA vaccines that have not been performed properly.

3 years ago
1 score
Reason: None provided.

Now that I'm going through the detail of your reply - I question if your a troll.

If you have questions ask them. Calling me a troll is an ad hominem attack designed specifically to discredit me without addressing an argument. Please do not do that again.

Several ingredients are redacted on page 7 so there's absolutely no way for you to check that the ingredients are the same

None of the ingredients are redacted. They are listed right there. For example:

[redacted] [4-hydroxybutyl)azanediyl)bis (hexane-6,1- diyl)bis(2-hexyldecanoate) (UNII: [redacted]

The ingredient is here. It is the exact same lipid as in Pfizers vaccine. Whatever is redacted is NOT the ingredient. In this case it looks like whatever name they gave it was redacted and the UNII was redacted. Why? I have no idea. They are easy to look up. The name is ALC-0315 as it shows on the link above. This list of ingredients of the Pfizer vaccine shows it. The second "redacted" ingredient can be found in the same way. They are the exact same molecules.

But don't forget about those optimized codons man.

As I explained, every single vaccine uses "optimized codons". Its just a term. The fact that they use rhetoric that suggests it is exclusive to COMIRNTY on page 7 suggests to me the person who wrote that section didn't understand what someone told them, because the Pfizer vaccine also has optimized codons, as I explained above.

The design of Pfizer/BioNTech and Moderna mRNA vaccines involves many different types of optimizations. Proper optimization of vaccine mRNA can reduce dosage required for each injection leading to more efficient immunization programs. The mRNA components of the vaccine need to have a 5′-UTR to load ribosomes efficiently onto the mRNA for translation initiation, optimized codon usage for efficient translation elongation, and optimal stop codon for efficient translation termination. Both 5′-UTR and the downstream 3′-UTR should be optimized for mRNA stability. The replacement of uridine by N1-methylpseudourinine (Ψ) complicates some of these optimization processes because Ψ is more versatile in wobbling than U. Different optimizations can conflict with each other, and compromises would need to be made. I highlight the similarities and differences between Pfizer/BioNTech and Moderna mRNA vaccines and discuss the advantage and disadvantage of each to facilitate future vaccine improvement. In particular, I point out a few optimizations in the design of the two mRNA vaccines that have not been performed properly.

3 years ago
1 score
Reason: None provided.

Now that I'm going through the detail of your reply - I question if your a troll.

If you have questions ask them. Calling me a troll is an ad hominem attack designed specifically to discredit me without addressing an argument. Please do not do that again.

Several ingredients are redacted on page 7 so there's absolutely no way for you to check that the ingredients are the same

None of the ingredients are redacted. They are listed right there. For example:

[redacted] [4-hydroxybutyl)azanediyl)bis (hexane-6,1- diyl)bis(2-hexyldecanoate) (UNII: [redacted]

The ingredient is here. It is the exact same lipid as in Pfizers vaccine. Whatever is redacted is NOT the ingredient. In this case it looks like whatever name they gave it was redacted and the UNII was redacted. Why? I have no idea. They are easy to look up. The name is ALC-0315 as it shows on the link above. This list of ingredients of the Pfizer vaccine shows it. The second "redacted" ingredient can be found in the same way. They are the exact same molecules.

But don't forget about those optimized codons man.

As I explained, every single vaccine uses "optimized codons". Its just a term. The fact that they use rhetoric that suggests it is exclusive to COMIRNTY on page 7 suggests to me the person who wrote that section didn't understand what someone told them, because the Pfizer vaccine also has optimized codons, as I explained above.

The design of Pfizer/BioNTech and Moderna mRNA vaccines involves many different types of optimizations. Proper optimization of vaccine mRNA can reduce dosage required for each injection leading to more efficient immunization programs. The mRNA components of the vaccine need to have a 5′-UTR to load ribosomes efficiently onto the mRNA for translation initiation, optimized codon usage for efficient translation elongation, and optimal stop codon for efficient translation termination. Both 5′-UTR and the downstream 3′-UTR should be optimized for mRNA stability. The replacement of uridine by N1-methylpseudourinine (Ψ) complicates some of these optimization processes because Ψ is more versatile in wobbling than U. Different optimizations can conflict with each other, and compromises would need to be made. I highlight the similarities and differences between Pfizer/BioNTech and Moderna mRNA vaccines and discuss the advantage and disadvantage of each to facilitate future vaccine improvement. In particular, I point out a few optimizations in the design of the two mRNA vaccines that have not been performed properly.

3 years ago
1 score
Reason: Original

Now that I'm going through the detail of your reply - I question if your a troll.

If you have questions ask them. Calling me a troll is an ad hominem attack designed specifically to discredit me without addressing an argument. Please do not do that again.

Several ingredients are redacted on page 7 so there's absolutely no way for you to check that the ingredients are the same

None of the ingredients are redacted. They are listed right there. For example:

[redacted] [4-hydroxybutyl)azanediyl)bis (hexane-6,1- diyl)bis(2-hexyldecanoate) (UNII: [redacted]

The ingredient is here. It is the exact same lipid as in Pfizers vaccine. Whatever is redacted is NOT the ingredient. In this case it looks like whatever name they gave it was redacted and the UNII was redacted. Why? I have no idea. They are easy to look up. The name is ALC-0315 as it shows on the link above. This list of ingredients of the Pfizer vaccine shows it. The second "redacted" ingredient can be found in the same way. They are the exact same molecules.

But don't forget about those optimized codons man.

As I explained, every single vaccine uses "optimized codons". Its just a term. The fact that they use it rhetoric that suggests it is exclusive to COMIRNTY on page 7 suggests to me the person who wrote that section didn't understand what someone told them, because the Pfizer vaccine also has optimized codons, as I explained above.

The design of Pfizer/BioNTech and Moderna mRNA vaccines involves many different types of optimizations. Proper optimization of vaccine mRNA can reduce dosage required for each injection leading to more efficient immunization programs. The mRNA components of the vaccine need to have a 5′-UTR to load ribosomes efficiently onto the mRNA for translation initiation, optimized codon usage for efficient translation elongation, and optimal stop codon for efficient translation termination. Both 5′-UTR and the downstream 3′-UTR should be optimized for mRNA stability. The replacement of uridine by N1-methylpseudourinine (Ψ) complicates some of these optimization processes because Ψ is more versatile in wobbling than U. Different optimizations can conflict with each other, and compromises would need to be made. I highlight the similarities and differences between Pfizer/BioNTech and Moderna mRNA vaccines and discuss the advantage and disadvantage of each to facilitate future vaccine improvement. In particular, I point out a few optimizations in the design of the two mRNA vaccines that have not been performed properly.

3 years ago
1 score