Methyl is just the active form of the vitamin. Having a copy or two of MTHFR causes the body to not be able to do its methylation process. So, a person with this issue can eat all the spinach they can, but will never convert any of that folate consumed to the active form. Basically, the body has no folate and B12 to use and this causes a ton of issues in the body, especially the heart. It has a huge impact on mitochondrial functionality and that leads to a multitude of health problems. Cardiovascular, fertility, brain function, mental health, nerve disorders, you name it... it probably has a direct link to those gene anomalies.

Would also like to add that half the population walks around with these gene mutations and have no idea.

Methyl is just the active form of the vitamin. Having a copy or two of MTHFR causes the body to not be able to do its methylation process. So, a person with this issue can eat all the spinach they can, but will never convert any of that folate consumed to the active form. Basically, the body has no folate and B12 to use and this causes a ton of issues in the body, especially the heart. It has a huge impact on mitochondrial functionality and that leads to a multitude of health problems. Cardiovascular, fertility, brain function, mental health, nerve disorders, you name it... it probably has a direct link to those gene anomalies.