Just this one alone should awaken people. Treating Multiple Myeloma (the OPs sciencedirect link):
Multiple myeloma (MM) is an incurable malignancy of plasma cells. Ivermectin is a US Food and Drug Administration-approved drug for antiparasitic use. Here, we showed that ivermectin exerted anti-MM effects and significantly synergized with proteasome inhibitors in vitro and in vivo. Ivermectin alone exhibited mild anti-MM activity in vitro. Further investigation suggested that ivermectin inhibited proteasome activity in the nucleus by repressing the nuclear import of proteasome subunits, such as PSMB5-7 and PSMA3-4. Therefore, ivermectin treatment caused the accumulation of ubiquitylated proteins and the activation of the UPR pathway in MM cells. Furthermore, ivermectin treatment caused DNA damage and DNA damage response (DDR) signaling pathway activation in MM cells. Ivermectin and bortezomib exhibited synergized anti-MM activity in vitro. The dual-drug treatment resulted in synergistic inhibition of proteasome activity and increased DNA damage. An in vivo study using a human MM cell line xenograft mouse model showed that ivermectin and bortezomib efficiently repressed MM tumor growth in vivo, while the dual-drug treatment was well tolerated by experimental animals. Overall, our results demonstrated that ivermectin alone or cotreated with bortezomib might be promising in MM treatment.
Note, that they want to add Big Pharma drugs to "help" Ivermection. "Well tolerated by experimental animals." Mixed feelings on this.
Edit: Plenty of articles from pre-covid, just never made the "news".
- Breast Cancer article from pre-covid (no bias then) https://pubmed.ncbi.nlm.nih.gov/27657889/ share if anyone you know is suffering.
- https://pubmed.ncbi.nlm.nih.gov/29511601/ The multitargeted drug ivermectin: from an antiparasitic agent to a repositioned cancer drug
- https://pubmed.ncbi.nlm.nih.gov/31215501/ Ivermectin reverses the drug resistance in cancer cells through EGFR/ERK/Akt/NF-κB pathway
- https://pubmed.ncbi.nlm.nih.gov/31885077/ Oral ivermectin for infants and children under 15 kg appears to be a safe and effective treatment for scabies. (2020, but added due to note about infants and body weight).
Just this one alone should awaken people. Treating Multiple Myeloma (the OPs sciencedirect link):
Multiple myeloma (MM) is an incurable malignancy of plasma cells. Ivermectin is a US Food and Drug Administration-approved drug for antiparasitic use. Here, we showed that ivermectin exerted anti-MM effects and significantly synergized with proteasome inhibitors in vitro and in vivo. Ivermectin alone exhibited mild anti-MM activity in vitro. Further investigation suggested that ivermectin inhibited proteasome activity in the nucleus by repressing the nuclear import of proteasome subunits, such as PSMB5-7 and PSMA3-4. Therefore, ivermectin treatment caused the accumulation of ubiquitylated proteins and the activation of the UPR pathway in MM cells. Furthermore, ivermectin treatment caused DNA damage and DNA damage response (DDR) signaling pathway activation in MM cells. Ivermectin and bortezomib exhibited synergized anti-MM activity in vitro. The dual-drug treatment resulted in synergistic inhibition of proteasome activity and increased DNA damage. An in vivo study using a human MM cell line xenograft mouse model showed that ivermectin and bortezomib efficiently repressed MM tumor growth in vivo, while the dual-drug treatment was well tolerated by experimental animals. Overall, our results demonstrated that ivermectin alone or cotreated with bortezomib might be promising in MM treatment.
Note, that they want to add Big Pharma drugs to "help" Ivermection. "Well tolerated by experimental animals." Mixed feelings on this.
Edit: Plenty of articles from pre-covid, just never made the "news".
- Breast Cancer article from pre-covid (no bias then) https://pubmed.ncbi.nlm.nih.gov/27657889/ share if anyone you know is suffering.
- https://pubmed.ncbi.nlm.nih.gov/29511601/ The multitargeted drug ivermectin: from an antiparasitic agent to a repositioned cancer drug
- https://pubmed.ncbi.nlm.nih.gov/31215501/ Ivermectin reverses the drug resistance in cancer cells through EGFR/ERK/Akt/NF-κB pathway
Just this one alone should awaken people. Treating Multiple Myeloma (the OPs sciencedirect link):
Multiple myeloma (MM) is an incurable malignancy of plasma cells. Ivermectin is a US Food and Drug Administration-approved drug for antiparasitic use. Here, we showed that ivermectin exerted anti-MM effects and significantly synergized with proteasome inhibitors in vitro and in vivo. Ivermectin alone exhibited mild anti-MM activity in vitro. Further investigation suggested that ivermectin inhibited proteasome activity in the nucleus by repressing the nuclear import of proteasome subunits, such as PSMB5-7 and PSMA3-4. Therefore, ivermectin treatment caused the accumulation of ubiquitylated proteins and the activation of the UPR pathway in MM cells. Furthermore, ivermectin treatment caused DNA damage and DNA damage response (DDR) signaling pathway activation in MM cells. Ivermectin and bortezomib exhibited synergized anti-MM activity in vitro. The dual-drug treatment resulted in synergistic inhibition of proteasome activity and increased DNA damage. An in vivo study using a human MM cell line xenograft mouse model showed that ivermectin and bortezomib efficiently repressed MM tumor growth in vivo, while the dual-drug treatment was well tolerated by experimental animals. Overall, our results demonstrated that ivermectin alone or cotreated with bortezomib might be promising in MM treatment.
Note, that they want to add Big Pharma drugs to "help" Ivermection. "Well tolerated by experimental animals." Mixed feelings on this.
Edit: Plenty of articles from pre-covid, just never made the "news".
- Breast Cancer article from pre-covid (no bias then) https://pubmed.ncbi.nlm.nih.gov/27657889/ share if anyone you know is suffering.
- https://pubmed.ncbi.nlm.nih.gov/29511601/ The multitargeted drug ivermectin: from an antiparasitic agent to a repositioned cancer drug
Just this one alone should awaken people. Treating Multiple Myeloma (the OPs sciencedirect link):
Multiple myeloma (MM) is an incurable malignancy of plasma cells. Ivermectin is a US Food and Drug Administration-approved drug for antiparasitic use. Here, we showed that ivermectin exerted anti-MM effects and significantly synergized with proteasome inhibitors in vitro and in vivo. Ivermectin alone exhibited mild anti-MM activity in vitro. Further investigation suggested that ivermectin inhibited proteasome activity in the nucleus by repressing the nuclear import of proteasome subunits, such as PSMB5-7 and PSMA3-4. Therefore, ivermectin treatment caused the accumulation of ubiquitylated proteins and the activation of the UPR pathway in MM cells. Furthermore, ivermectin treatment caused DNA damage and DNA damage response (DDR) signaling pathway activation in MM cells. Ivermectin and bortezomib exhibited synergized anti-MM activity in vitro. The dual-drug treatment resulted in synergistic inhibition of proteasome activity and increased DNA damage. An in vivo study using a human MM cell line xenograft mouse model showed that ivermectin and bortezomib efficiently repressed MM tumor growth in vivo, while the dual-drug treatment was well tolerated by experimental animals. Overall, our results demonstrated that ivermectin alone or cotreated with bortezomib might be promising in MM treatment.
Note, that they want to add Big Pharma drugs to "help" Ivermection. "Well tolerated by experimental animals." Mixed feelings on this.
Edit: Breast Cancer article from pre-covid (no bias then) https://pubmed.ncbi.nlm.nih.gov/27657889/ share if anyone you know is suffering.
Just this one alone should awaken people. Treating Multiple Myeloma (the OPs sciencedirect link):
Multiple myeloma (MM) is an incurable malignancy of plasma cells. Ivermectin is a US Food and Drug Administration-approved drug for antiparasitic use. Here, we showed that ivermectin exerted anti-MM effects and significantly synergized with proteasome inhibitors in vitro and in vivo. Ivermectin alone exhibited mild anti-MM activity in vitro. Further investigation suggested that ivermectin inhibited proteasome activity in the nucleus by repressing the nuclear import of proteasome subunits, such as PSMB5-7 and PSMA3-4. Therefore, ivermectin treatment caused the accumulation of ubiquitylated proteins and the activation of the UPR pathway in MM cells. Furthermore, ivermectin treatment caused DNA damage and DNA damage response (DDR) signaling pathway activation in MM cells. Ivermectin and bortezomib exhibited synergized anti-MM activity in vitro. The dual-drug treatment resulted in synergistic inhibition of proteasome activity and increased DNA damage. An in vivo study using a human MM cell line xenograft mouse model showed that ivermectin and bortezomib efficiently repressed MM tumor growth in vivo, while the dual-drug treatment was well tolerated by experimental animals. Overall, our results demonstrated that ivermectin alone or cotreated with bortezomib might be promising in MM treatment.
Note, that they want to add Big Pharma drugs to "help" Ivermection. "Well tolerated by experimental animals." Mixed feelings on this.