Nicotine Gum: Delivers nicotine quickly through the lining of the mouth, causing rapid but short-lived increases in nicotine concentration. This leads to transient spikes in cellular nicotine levels, with periods of higher concentration followed by a rapid decline.

Nicotine Patch: Provides a slow and steady release of nicotine through the skin, resulting in a stable and sustained increase in nicotine levels in the bloodstream. This steady delivery maintains a consistent cellular nicotine concentration over a prolonged period.

Nicotine Gum: The intermittent spikes in nicotine levels prevent prolonged receptor activation, reducing the risk of long-term receptor desensitization and cellular adaptation, You end up with peaks of high concentrations.

Nicotine Patch: Continuous exposure to nicotine leads to sustained receptor activation, which can result in receptor desensitization or downregulation over time due to prolonged cellular exposure. You end up with steady but lower concentrations.

Nicotine Gum: Delivers nicotine quickly through the lining of the mouth, causing rapid but short-lived increases in nicotine concentration. This leads to transient spikes in cellular nicotine levels, with periods of higher concentration followed by a rapid decline. You end up with peaks of high concentrations.

Nicotine Patch: Provides a slow and steady release of nicotine through the skin, resulting in a stable and sustained increase in nicotine levels in the bloodstream. This steady delivery maintains a consistent cellular nicotine concentration over a prolonged period. You end up with steady but lower concentrations.

Nicotine Gum: The intermittent spikes in nicotine levels prevent prolonged receptor activation, reducing the risk of long-term receptor desensitization and cellular adaptation.

Nicotine Patch: Continuous exposure to nicotine leads to sustained receptor activation, which can result in receptor desensitization or downregulation over time due to prolonged cellular exposure.