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Reason: None provided.

However, no one mentions that cell death can result in over production of the spike protein,

I have no idea where you are getting such an idea, but even if true (for which there is no impetus nor evidence) then what?

Spike proteins are a transmembrane protein. They live INSIDE the membrane. So you are suggesting that a transmembrane protein that only can exist in a membrane is making little bubbles of cells float throughout the body?

Cell death is a process where the cell is broken up into small bubbles (blebs) and engulfed by the cells designed to eat them. The contents are then destroyed. They never enter the cytoplasm of the phagocyte (the cell doing the eating). There are no free floating spike proteins. Its basically impossible. Could there be free floating blebs with spike proteins? I find that extremely unlikely but I'll give it to you. What then? Why then it still gets eaten.

But lets say this hypothetical bleb escapes all that, what then? How does it find an ACE-2 receptor to dock to? That's a miracle worth solving.

So it goes into the blood stream (by some miracle) to seek out these receptors and gets eaten by cells in the blood designed for that express purpose. That's what happens to foreign bodies in the blood.

Bummer.

But this is the miracle bleb. Lets say it escapes all that.

Somehow it finds a path out of the blood vessels into the lumen of some tissue. Not going to happen, but I'll give it to you for this discussion.

Lets say, by some miracle it just so happened to be in a place with cells where ACE-2 is expressed and this theoretical bleb, that made it all this way, has finally found its mate.

Guess what happens? It gets eaten and destroyed. There is no mechanism on the spike protein to release anything into the cytoplasm of the new cells. That's what the rest of the virus is for. This miraculous spike protein expressing bleb would dock, be endocytosed, and consumed in the resulting lysosome.

Bummer.

The spike protein is not a virus. Its not a miracle. Its just a protein that docks to a receptor. What happens next is whatever would normally happen. If the spike protein is attached to a virus, it does its virus thing. If the spike protein is attached to the dead bleb, it gets eaten. Its that simple.

3 years ago
1 score
Reason: None provided.

However, no one mentions that cell death can result in over production of the spike protein,

I have no idea where you are getting such an idea, but even if true (for which there is no impetus nor evidence) then what?

Spike proteins are a transmembrane protein. They live INSIDE the membrane. So you are suggesting that a transmembrane protein that only can exist in a membrane is making little bubbles of cells float throughout the body?

Cell death is a process where the cell is broken up into small bubbles and engulfed by the cells designed to eat them. The contents are then destroyed. They never enter the cytoplasm of the phagocyte (the cell doing the eating). There are no free floating spike proteins. Its basically impossible. Could there be free floating blebs with spike proteins? I find that extremely unlikely but I'll give it to you. What then? Why then it still gets eaten.

But lets say this hypothetical bleb escapes all that, what then? How does it find an ACE-2 receptor to dock to? That's a miracle worth solving.

So it goes into the blood stream (by some miracle) to seek out these receptors and gets eaten by cells in the blood designed for that express purpose. That's what happens to foreign bodies in the blood.

Bummer.

But this is the miracle bleb. Lets say it escapes all that.

Somehow it finds a path out of the blood vessels into the lumen of some tissue. Not going to happen, but I'll give it to you for this discussion.

Lets say, by some miracle it just so happened to be in a place with cells where ACE-2 is expressed and this theoretical bleb, that made it all this way, has finally found its mate.

Guess what happens? It gets eaten and destroyed. There is no mechanism on the spike protein to release anything into the cytoplasm of the new cells. That's what the rest of the virus is for. This miraculous spike protein expressing bleb would dock, be endocytosed, and consumed in the resulting lysosome.

Bummer.

The spike protein is not a virus. Its not a miracle. Its just a protein that docks to a receptor. What happens next is whatever would normally happen. If the spike protein is attached to a virus, it does its virus thing. If the spike protein is attached to the dead bleb, it gets eaten. Its that simple.

3 years ago
1 score
Reason: None provided.

However, no one mentions that cell death can result in over production of the spike protein,

I have no idea where you are getting such an idea, but even if true (for which there is no impetus nor evidence) then what?

Spike proteins are a transmembrane protein. They live INSIDE the membrane. So you are suggesting that a transmembrane protein that only can exist in a membrane is making little bubbles of cells float throughout the body?

Cell death is a process where the cell is broken up into small bubbles and engulfed by the cells designed to eat them. The contents are then destroyed. They never enter the cytoplasm of the phagocyte (the cell doing the eating). There are no free floating spike proteins. Its basically impossible. Could there be free floating blebs with spike proteins? I find that extremely unlikely but I'll give it to you. What then? Why then it still gets eaten.

But lets say this hypothetical bleb escapes all that, what then? How does it find an ACE-2 receptor to dock to? That's a miracle worth solving.

So it goes into the blood stream (by some miracle) to seek out these receptors and gets eaten by cells in the blood designed for that express purpose. That's what happens to foreign bodies in the blood.

Bummer.

But this is the miracle bleb. Lets say it escapes all that.

Somehow it finds a path out of the blood vessels into the lumen of some tissue. Not going to happen, but I'll give it to you for this discussion.

Lets say, by some miracle it just so happened to be in a place with cells where ACE-2 is expressed and this theoretical bleb, that made it all this way, has finally found its mate.

Guess what happens? It gets eaten and destroyed. There is no mechanism on the spike protein to release anything into the cytoplasm of the new cells. That's what the rest of the virus is for. This miraculous spike protein expressing bleb would dock, be endocytosed, and consumed in the resulting liposome.

Bummer.

The spike protein is not a virus. Its not a miracle. Its just a protein that docks to a receptor. What happens next is whatever would normally happen. If the spike protein is attached to a virus, it does its virus thing. If the spike protein is attached to the dead bleb, it gets eaten. Its that simple.

3 years ago
1 score
Reason: Original

However, no one mentions that cell death can result in over production of the spike protein,

I have no idea where you are getting such an idea, but even if true (for which there is no impetus nor evidence) then what?

Spike proteins are a transmembrane protein. They live INSIDE the membrane. So you are suggesting that a transmembrane protein that only can exist in a membrane is making little bubbles of cells float throughout the body?

Cell death is a process where the cell is broken up into small bubbles and engulfed by the cells designed to eat them. The contents are then destroyed. They never enter the cytoplasm of the phagocyte (the cell doing the eating). There are no free floating spike proteins. Its basically impossible. Could there be free floating blebs with spike proteins? I find that extremely unlikely but I'll give it to you. What then? Why then it still gets eaten.

But lets say this hypothetical bleb escapes all that, what then? How does it find an ACE-2 receptor to dock to? That's a miracle worth solving.

So it goes into the blood stream to seek out these receptors and gets eaten, because that's what happens to foreign bodies in the blood.

Bummer.

But this is the miracle bleb. Lets say it escapes all that.

Somehow it finds a path out of the blood vessels into the lumen of some tissue. Not going to happen, but I'll give it to you for this discussion.

Lets say, by some miracle it just so happened to be in a place with cells where ACE-2 is expressed and this theoretical bleb, that made it all this way, has finally found its mate.

Guess what happens? It gets eaten and destroyed. There is no mechanism on the spike protein to release anything into the cytoplasm of the new cells. That's what the rest of the virus is for. This miraculous spike protein expressing bleb would dock, be endocytosed, and consumed in the resulting liposome.

Bummer.

The spike protein is not a virus. Its not a miracle. Its just a protein that docks to a receptor. What happens next is whatever would normally happen. If the spike protein is attached to a virus, it does its virus thing. If the spike protein is attached to the dead bleb, it gets eaten. Its that simple.

3 years ago
1 score