normally incumbents in a party will not be challenged in a primary - if the feeling within said political party is that they've been reasonable representatives of the party's goals

RINO, such as these senators, are universally reviled by the majority of people in the party by which they ran for and hold office

They will now be sure to be challenged in the next election primaries in which they need to run for re-election for their office, and those challengers are going to make sure to call them out and condemn them for their treachery. And right now the people that voted for Pres. Trump are infuriated at the RINOs (effectively traitors) and despise them