Ethically, a humanized mouse can be one where it has been genetically altered to produce human variants of a number of genes. Typically, we're very genetically similar to many mammals, but small differences in code can have huge effects 'down stream' so to speak, so to make mouse models more closely predictive of what to expect in humans, little changes like that are a big deal
#HOWEVER
It can also refer to mice who have been transplanted with human cells. Where possible, this obviously closes the gap even further... but in truth you're not really running a mouse trial, you're running a human trial in a mouse incubator. Which SHOULD raise questions that any other human trial would... like consent of the patient. But in this case doesn't. Where did those human cells come from again?
Isn't it lovely how the evil hide behind definitions? They lump the reprehensible under an umbrella of acceptable, change definitions to include them, all to manipulate your reaction?
"We've been doing humanized mouse trials for decades, I don't understand what all this anger is about. These people are so anti-science"
Some 50 year old researcher who simply doesn't know.
Ethically, a humanized mouse can be one where it has been genetically altered to produce human variants of a number of genes. Typically, we're very genetically similar to many mammals, but small differences in code can have huge effects 'down stream' so to speak, so to make mouse models more closely predictive of what to expect in humans, little changes like that are a big deal
#HOWEVER
It can also refer to mice who have been transplanted with human cells. Where possible, this obviously closes the gap even further... but in truth you're not really running a mouse trial, you're running a human trial in a mouse incubator. Which SHOULD raise questions that any other human trial would... like consent of the patient. But in this case doesn't. Where did those human cells come from again?
Isn't it lovely how the evil hide behind definitions? They lump the reprehensible under an umbrella of acceptable, change definitions to include them, all to manipulate your reaction?
"We've been doing humanized mouse trials for decades, I don't understand what all this anger is about. These people are so anti-science"
Giving mice human genes so that they can create a virus in a mouse that can be spread to humans.
That is an example use case, yes.