The cell is constantly clearing surface proteins; recycling them. Especially a protein like the S protein that has no cytoskeletal and extracellular matrix anchors. So the actual proteins that get expressed on the surface will absolutely be cleared in relatively short order. The mRNA itself has a half life of a couple days. Within two weeks any infected cells should be clear of any spike producing mRNA.
According to this paper which tested PEG clearance (polyethelene glycol, which coats the nanoparticle) the body breaks it down and clears it relatively quickly.
The lipids that make up the rest of the nanoparticles will be integrated into the cell walls. But cell walls are in constant flux, and those lipids will almost certainly be broken down in short order as well. That is of course if a vaccine infected cell survives. Since the point of the vaccine is to cause an immune response which will likely kill any infected cell through induced apoptosis, the most probable outcome is that the entire thing will be consumed and cleared very quickly by this mechanism.
Our entire bodies are in constant flux. It is likely that not a single atom or molecule of you is one that you were born with. Everything gets replaced all the time. Some things can last longer than others, especially things for which there is no breakdown mechanism (can't enter any metabolic pathway), but everything gets cleared eventually. We are after all, biological machines designed for that exact purpose.
So yes, all of the vaccine will go away. I would guess very nearly every single molecule of it is gone within two weeks. I would like to see studies on the lipid clearance itself, but having looked at the molecules I see no obvious issues. That doesn't really mean much except there is nothing glaring. Biology is complicated and everything requires testing. But as for the actual nasty shit, the mRNA and S protein, that stuff has very clear breakdown pathways, so even if a cell survives the experience, that stuff will be gone in a couple weeks for sure.
The cell is constantly clearing surface proteins; recycling them. Especially a protein like the S protein that has no cytoskeletal and extracellular matrix anchors. So the actual proteins that get expressed on the surface will absolutely be cleared in relatively short order. The mRNA itself has a half life of a couple days. Within two weeks any infected cells should be clear of any spike producing mRNA.
According to this paper which tested PEG clearance (polyethelene glycol, which coats the nanoparticle) the body breaks it down and clears it relatively quickly.
The lipids that make up the rest of the nanoparticles will be integrated into the cell walls. But cell walls are in constant flux, and those lipids will almost certainly be broken down in short order as well. That is of course if a vaccine infected cell survives. Since the point of the vaccine is to cause an immune response which will likely kill any infected cell through induced apoptosis, the most probable outcome is that the entire thing will be consumed and cleared very quickly by this mechanism.
Our entire bodies are in constant flux. It is likely that not a single atom or molecule of you is one that you were born with. Everything gets replaced all the time. Some things can last longer than others, especially things for which there is no breakdown mechanism (can't enter any metabolic pathway), but everything gets cleared eventually. We are after all, biological machines designed for that exact purpose.
So yes, all of the vaccine will go away. I would guess very nearly every single molecule of it is gone within two weeks. I would like to see studies on the lipid clearance itself, but having looked at the molecules I see no obvious issues. That doesn't really mean much except there is nothing glaring. Biology is complicated and everything requires testing. But as for the actual nasty shit, the mRNA and S protein, that stuff has very clear breakdown pathways, so even if a cell survives the experience, that stuff will be gone in a couple weeks for sure.