Following a single 200 mg oral dose of hydroxychloroquine sulfate to healthy males, the mean peak blood concentration of hydroxychloroquine was 129.6 ng/mL, reached in 3.26 hours with a half-life of 537 hours (22.4 days)
That means that even on day 3, the 1600mgs you received in the first 6 hours still counts for around ~1200mgs floating around in you! So even though you are now only receiving 800mgs a day, at the end of day 3 you have 4,800mgs still active
If the lethal dose is an upwards of ~30mg/kg an 185lb individual receives a lethal dose at 2,400mgs. This 12 day trial maxes out at a 11,500mg active load by the end using the 170hr halflife.
NOTE: Pharmacokinetics is not what I do for a living. Localization and what you measure all matter, and I recognize my ignorance (my field is tangential but unrelated to pharmacology). But this protocol seems purposefully designed to kill the participants. At the very least, to force the administrating physicians to end their participation early due to 'health risks to the patients' which is exactly what we heard.
I knew they were testing too high in some of these trials, but I never sat down to really work out how absurd it was.
Plasma half life of HCQ is 123 DAYS. It is incredible to me that this dose could have been recommended and then FOLLOWED mindlessly by Doctors and Pharmacists and kill 100K people. Every time this order would have been entered into a pharmacy computer the software would throw a Dosage Error alert and have to be overridden by a Pharmacist. WTAF ??
CRITICAL
https://www.aliem.com/hydroxychloroquine-toxicity/
https://medical-en.nneandersphysiologicalliteracy.com/hydroxychloroquine-has-a-half-life-of-2963-hours-123-5-days-hydroxychloroquine-toxicity/
That means that even on day 3, the 1600mgs you received in the first 6 hours still counts for around ~1200mgs floating around in you! So even though you are now only receiving 800mgs a day, at the end of day 3 you have 4,800mgs still active
If the lethal dose is an upwards of ~30mg/kg an 185lb individual receives a lethal dose at 2,400mgs. This 12 day trial maxes out at a 11,500mg active load by the end using the 170hr halflife.
NOTE: Pharmacokinetics is not what I do for a living. Localization and what you measure all matter, and I recognize my ignorance (my field is tangential but unrelated to pharmacology). But this protocol seems purposefully designed to kill the participants. At the very least, to force the administrating physicians to end their participation early due to 'health risks to the patients' which is exactly what we heard.
I knew they were testing too high in some of these trials, but I never sat down to really work out how absurd it was.
Plasma half life of HCQ is 123 DAYS. It is incredible to me that this dose could have been recommended and then FOLLOWED mindlessly by Doctors and Pharmacists and kill 100K people. Every time this order would have been entered into a pharmacy computer the software would throw a Dosage Error alert and have to be overridden by a Pharmacist. WTAF ??