Observed in similar vaccine attempts in the past such as MERS and SARS. Non-neutralizing (ie: ineffective) antibodies bind to target on the real virus when encountered. Since virus is tagged with the AB, specialized white blood cells do their job and engulf the virus for destruction and removal.
Because the virus is still viable (not neutralized) it's does it's thing, taking over the WBC and making many, many copies of itself until the WBC ruptures releasing new viruses and cycle continues. This has essentially provided the virus for an additional pathway of infection. Double whammy is that the WBCs you need to clear infection are destroyed while also making more viruses.
Net effect, much more severe disease and quite often, Death.
Lot of virologists, immunologists, and vaccinologists on alternative media explain better than I. Of note is that Wiki sanitized their entry on ADE after all of this became an issue.
Antibody Dependent Enhancement
Observed in similar vaccine attempts in the past such as MERS and SARS. Non-neutralizing (ie: ineffective) antibodies bind to target on the real virus when encountered. Since virus is tagged with the AB, specialized white blood cells do their job and engulf the virus for destruction and removal.
Because the virus is still viable (not neutralized) it's does it's thing, taking over the WBC and making many, many copies of itself until the WBC ruptures releasing new viruses and cycle continues. This has essentially provided the virus for an additional pathway of infection. Double whammy is that the WBCs you need to clear infection are destroyed while also making more viruses.
Net effect, much more severe disease and quite often, Death.
Lot of virologists, immunologists, and vaccinologists on alternative media explain better than I. Of note is that Wiki sanitized their entry on ADE after all of this became an issue.