It's different state by state. But they would have to fight in court and show you did something against the rules to be fired. It's not simply because you were laid off. I seriously doubt they could deny you unemployment after they fire you for refusing to get the death VAX. I've seen people get fired for being practically incompetent and still get unemployment. Regardless, if you quit you definitely won't get it. Also, we pay unemployment insurance, it comes out of our paychecks. Take advantage of it. Most companies won't fight it.