They approved a vax that I’m pretty sure nobody in the United States can get. So misleading. Media is culpable for pushing the lie that the Pfizer vax (implying bnt162b2) is approved so begin the mandates. I believe you can buy time demanding the fda approved jab. Anyone says they’re the same - clarify that you need the jab witb optimized codons! Who would want a jab that’s unnaproved witb suboptimal codons! (I’m laughing as I write this).
I am not seeing any indication that there is anything "misleading" here.
If you have further evidence that approving the BioNTech is not the same as approving the Pfizer, when they both co-developed this exact vaccine (with the exact same serial number), please let me know.
As for the CORMIRNATY having "optimized codons" thats just jargon. All of the vaccines have "optimized codons". That just means that they changed some of the nucleosides to increase half-life of the mRNA in the cytosol (allowing for longer "effectiveness") and/or changed some of the nucleosides for other reasons. The way RNA to Amino acid coding works, with many redundancies in the code, allows for many potential modifications in RNA for whatever reason, while producing the same exact protein.
The information presented suggests that both Pfizer and CORMIRNATY have the exact same "optimized codons", suggesting this is only evidence of their sameness, not evidence of something different.
As for what it says on page 14:
The repeat dose toxicity evaluations were conducted on COMIRNATY and a similar
vaccine termed BNT162b2 (V8). COMIRNATY and BNT162b2 (V8) have identical amino
acid sequences of the encoded antigens but COMIRNATY includes the presence of
optimized codons to improve antigen expression.
I can't rectify that. Maybe whoever wrote it misunderstood, or maybe there is something more to be found, but by the serial number they appear to be the exact same.
Now that I'm going through the detail of your reply - I question if your a troll. Several ingredients are redacted on page 7 so there's absolutely no way for you to check that the ingredients are the same. Do you have the ability to unredact the ingredients? The FDA paper clarified they used the same antigen encoding, which yes would be the same. But don't forget about those optimized codons man.
Now that I'm going through the detail of your reply - I question if your a troll.
If you have questions ask them. Calling me a troll is an ad hominem attack designed specifically to discredit me without addressing an argument. Please do not do that again.
Several ingredients are redacted on page 7 so there's absolutely no way for you to check that the ingredients are the same
None of the ingredients are redacted. They are listed right there. For example:
The ingredient is here. It is the exact same lipid as in Pfizers vaccine. Whatever is redacted is NOT the ingredient. In this case it looks like whatever name they gave it was redacted and the UNII was redacted. Why? I have no idea. They are easy to look up. The name is ALC-0315 as it shows on the link above. This list of ingredients of the Pfizer vaccine shows it. The second "redacted" ingredient can be found in the same way. They are the exact same molecules.
But don't forget about those optimized codons man.
As I explained, every single vaccine uses "optimized codons". Its just a term. The fact that they use rhetoric that suggests it is exclusive to COMIRNTY on page 14 suggests to me the person who wrote that section didn't understand what someone told them, because the Pfizer vaccine also has optimized codons, as I explained above.
The design of Pfizer/BioNTech and Moderna mRNA vaccines involves many different types of optimizations. Proper optimization of vaccine mRNA can reduce dosage required for each injection leading to more efficient immunization programs. The mRNA components of the vaccine need to have a 5′-UTR to load ribosomes efficiently onto the mRNA for translation initiation, optimized codon usage for efficient translation elongation, and optimal stop codon for efficient translation termination. Both 5′-UTR and the downstream 3′-UTR should be optimized for mRNA stability. The replacement of uridine by N1-methylpseudourinine (Ψ) complicates some of these optimization processes because Ψ is more versatile in wobbling than U. Different optimizations can conflict with each other, and compromises would need to be made. I highlight the similarities and differences between Pfizer/BioNTech and Moderna mRNA vaccines and discuss the advantage and disadvantage of each to facilitate future vaccine improvement. In particular, I point out a few optimizations in the design of the two mRNA vaccines that have not been performed properly.
They approved a vax that I’m pretty sure nobody in the United States can get. So misleading. Media is culpable for pushing the lie that the Pfizer vax (implying bnt162b2) is approved so begin the mandates. I believe you can buy time demanding the fda approved jab. Anyone says they’re the same - clarify that you need the jab witb optimized codons! Who would want a jab that’s unnaproved witb suboptimal codons! (I’m laughing as I write this).
I'm having a difficult time rectifying this statement. I believe they are the exact same vaccine.
According to the FDA release above, the COMIRNATY vaccine has the exact same ingredients, including the exact same mRNA strand (bnt162b2).
On page 7 (bottom) it lists the ingredients. Every ingredient is the same as the Pfizer vaccine, including the first one (mRNA).
Looking up UNII: 5085ZFP6SJ it says:
Looking up TOZINAMERAN it says:
They are the exact same molecule.
I am not seeing any indication that there is anything "misleading" here.
If you have further evidence that approving the BioNTech is not the same as approving the Pfizer, when they both co-developed this exact vaccine (with the exact same serial number), please let me know.
As for the CORMIRNATY having "optimized codons" thats just jargon. All of the vaccines have "optimized codons". That just means that they changed some of the nucleosides to increase half-life of the mRNA in the cytosol (allowing for longer "effectiveness") and/or changed some of the nucleosides for other reasons. The way RNA to Amino acid coding works, with many redundancies in the code, allows for many potential modifications in RNA for whatever reason, while producing the same exact protein.
The information presented suggests that both Pfizer and CORMIRNATY have the exact same "optimized codons", suggesting this is only evidence of their sameness, not evidence of something different.
As for what it says on page 14:
I can't rectify that. Maybe whoever wrote it misunderstood, or maybe there is something more to be found, but by the serial number they appear to be the exact same.
Now that I'm going through the detail of your reply - I question if your a troll. Several ingredients are redacted on page 7 so there's absolutely no way for you to check that the ingredients are the same. Do you have the ability to unredact the ingredients? The FDA paper clarified they used the same antigen encoding, which yes would be the same. But don't forget about those optimized codons man.
If you have questions ask them. Calling me a troll is an ad hominem attack designed specifically to discredit me without addressing an argument. Please do not do that again.
None of the ingredients are redacted. They are listed right there. For example:
The ingredient is here. It is the exact same lipid as in Pfizers vaccine. Whatever is redacted is NOT the ingredient. In this case it looks like whatever name they gave it was redacted and the UNII was redacted. Why? I have no idea. They are easy to look up. The name is ALC-0315 as it shows on the link above. This list of ingredients of the Pfizer vaccine shows it. The second "redacted" ingredient can be found in the same way. They are the exact same molecules.
As I explained, every single vaccine uses "optimized codons". Its just a term. The fact that they use rhetoric that suggests it is exclusive to COMIRNTY on page 14 suggests to me the person who wrote that section didn't understand what someone told them, because the Pfizer vaccine also has optimized codons, as I explained above.
Apologize for the troll comment. You have responded with honor as we dig. I as we dig.