Through OSHA (Occupational Safety and Health Administration). I.E. viewing unvaxxed employees as making the workplace unsafe. Businesses that don't comply will be fined.
Patriots should have fought hard against OSHA in the first place, because the whole concept violates the Constitution directly.
"A senior administration official estimated that this new OSHA requirement will cover about 80 million workers and businesses that do not comply with the agency’s rule can face substantial fees"
They essentially ruled the 10th "more of a guide than a rule"... Activist courts do all kinds of illegal things and most of the federal government today is illegal if the 10th is reinstated.