Enriching anon post with links. Original at: https://archive.vn/fqzW9
------------ Part I
mRNA technology has been around for a while [1]. What kept it from being used in widespread vaccination was lacking a way to protect the mRNA long enough to get inside of cells and to ribosomes, where it can be "read" to construct a protein [2]. Instead of admitting this they (Moderna, Phizer, etc.) went ahead with an extremely lipid-soluble coating [3]. That would guarantee the mRNA injected easily and quickly passed through cell membranes and gets to the site of action (ribosomes.) [4] But it also meant that, unlike other vaccines, which have their particles taken up in normal lymph flow and end up in lymph-nodes local to site of injection where foreign, antigenic molecules are processed by dendritic cells and stay in the extracellular space otherwise (outside and in-between cells, the interstitium) [5], the mRNA injected in these vaccines ends up everywhere , easily passing from the interstitium to the blood stream and across the blood-brain barrier [6].
[1] THERE’S A BIG GAP BETWEEN WHEN THE FIRST MRNA FLU VACCINE WAS TESTED IN MICE IN THE 1990S AND WHEN THE FIRST MRNA VACCINES FOR RABIES WERE TESTED IN HUMANS IN 2013. https://publichealth.jhu.edu/2021/the-long-history-of-mrna-vaccines
[2] The biggest challenge was that mRNA would be taken up by the body and quickly degraded before it could “deliver” its message—the RNA transcript—and be read into proteins in the cells. https://publichealth.jhu.edu/2021/the-long-history-of-mrna-vaccines
[3] Lipid nanoparticles are a vital component of the Pfizer/BioNTech and Moderna mRNA COVID-19 vaccines, playing a key role in protecting and transporting the mRNA effectively to the right place in cells. https://www.cas.org/resource/blog/understanding-nanotechnology-covid-19-vaccines
[4] The mRNA vaccines encode for SARS-CoV-2 antigen (spike protein) using the host ribosomes. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8473088/
Upon intramuscular (IM) administration, the LNP system enables the uptake by host cells and the delivery of mRNA inside the cytosol, where the translation of the mRNA sequence into the S protein occurs in the ribosomes. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8032477/
[5] In particular, vaccines containing live pathogens effectively form antibodies in the lymph nodes closest to the vaccination site. https://thl.fi/en/web/infectious-diseases-and-vaccinations/information-about-vaccinations/adverse-effects-of-vaccinations/adverse-effects-by-symptoms/enlarged-lymph-nodes-after-vaccination
As lymph flows through the lymphatic vessels, it passes through the lymph nodes. The lymph node is the major site for the interaction of lymphocytes with antigen during a primary adaptive response.
In Primer to the Immune Response (Second Edition), 2014
The major route of entry for antigens and pathogens is by the afferent lymph flow,
Fundamentals of Toxicologic Pathology (Second Edition), 2010
Dendritic cells (DCs), named for their probing, ‘tree-like’ or dendritic shapes, are responsible for the initiation of adaptive immune responses and hence function as the ‘sentinels’ of the immune system.
https://www.immunology.org/public-information/bitesized-immunology/cells/dendritic-cells
"In the journal Scientific Reports, researchers describe the interstitium as “a previously unrecognized, though widespread, macroscopic, fluid-filled space within and between tissues.” It’s made up of collagen bundles surrounding fluid pockets that may contain up to 20 percent of all the fluid in our bodies."
https://livenaturallymagazine.com/interstitium-your-stealth-organ
The blood-brain barrier (BBB) is a diffusion barrier, which impedes influx of most compounds from blood to brain. Dysfunction of the BBB, for example, impairment of the TJ seal, complicates a number of neurologic diseases including stroke and neuroinflammatory disorders.
https://pubmed.ncbi.nlm.nih.gov/15207256/
In fact, LNPs are often used to overcome the problem of the BBB blocking medical drugs from entering the brain. https://medium.com/microbial-instincts/concerns-of-lipid-nanoparticle-carrying-mrna-vaccine-into-the-brain-what-to-make-of-it-42b1a98dae27
"Hence, lipid nanoformulations, SLNs (solid lipid nanoparticles) and NLCs (nanostructured lipid carriers) emerged to overcome these challenges by utilizing physiological transport mechanisms across blood-brain barrier," https://pubmed.ncbi.nlm.nih.gov/32116044/
[6] Postmortem molecular mapping by real-time polymerase chain reaction revealed relevant SARS-CoV-2 cycle threshold values in all organs examined (oropharynx, olfactory mucosa, trachea, lungs, heart, kidney and cerebrum) except for the liver and olfactory bulb. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8051011/
------------ Part II
Compared with getting a virus, the virus is only able to bond with and enter some cells; injecting its genetic material and taking over production to make more virus. [7] It is limited to cells displaying molecules each virus is capable of binding to (in the case of SARS-CoV-2 this is a molecule called ACE2.) [8] In "normal" vaccination only dendritic and a few other immune cells (which are designed to ingest and deal with antigenic molecules) end up with viral proteins in them. These specific cells are part of the immune reaction that ends up with long term and robust immunity. With mRNA vaccination the injection is in the deltoid (most of the time) [9] but the particles of mRNA move easily in and out of cells and across biological membranes. Any cell, and subsequently its ribosomes, which come into contact with the exogenous mRNA will start to produce the altered SARS-CoV-2 spike proteins that the mRNA instructs for. [10]
[7] The virus then hijacks the host cell’s protein-making machinery to translate its RNA into new copies of the virus. https://www.technologyreview.com/2020/04/15/999476/explainer-how-does-the-coronavirus-work/
[8] The virus’s protein spikes attach to a protein on the surface of cells, called ACE2. Normally, ACE2 plays a role in regulating blood pressure. https://www.technologyreview.com/2020/04/15/999476/explainer-how-does-the-coronavirus-work/
[9] slide 11 https://covid-slides.idea.medicine.uw.edu/uploads/53/covid19_mrna_vaccines_mechanism__wide.pdf
[10] Vaccine researchers had assumed that novel mRNA COVID vaccines would behave like “traditional” vaccines and the vaccine spike protein — responsible for infection and its most severe symptoms — would remain mostly in the vaccination site at the shoulder muscle. Instead, the Japanese data showed that the infamous spike protein of the coronavirus gets into the blood where it circulates for several days post-vaccination and then accumulated in organs and tissues including the spleen, bone marrow, the liver, adrenal glands, and in “quite high concentrations” in the ovaries.
Stephanie Seneff, a senior research scientist at Massachusetts Institute of Technology, told LifeSiteNews. “It is now clear” that vaccine content is being delivered to the spleen and the glands, including the ovaries and the adrenal glands. “The released spike protein is being shed into the medium and then eventually reaches the bloodstream causing systemic damage. ACE2 receptors are common in the heart and brain, and this is how the spike protein causes cardiovascular and cognitive problems,” Seneff said. https://www.lifesitenews.com/news/vaccine-researcher-admits-big-mistake-says-spike-protein-is-dangerous-toxin/
The S1 protein of SARS-CoV-2 crosses the blood–brain barrier in mice https://www.nature.com/articles/s41593-020-00771-8
SARS-CoV-2) proteins were measured in longitudinal plasma samples collected from 13 participants who received two doses of mRNA-1273 vaccine. Spike protein was detectable in 3 of 13 participants an average of 15 days after the first injection. https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciab465/6279075
------------ Part III
In the normal course of cellular function the master copy of your build and operating instructions (DNA) has a page or chapter photocopied as needed (mRNA) and sent out to factories (ribosomes) which read the instructions and build proteins according to them. [11] During this process, whatever protein is being made is reported back to the immune system. [12] This happens by each of your cells taking one of the things its factories are making and displaying them on the outside of their cell membrane. You can think of this as a sign at city limits which has an example of what each factory is making in a city. Security (T-Cells of the immune system) come by, but can't get inside, they just look at the sign to see if something is off. [13] If something is, they can nuke the whole city (induce lysis) or tag the sign for other bulldozer immune cells to come by and level it. [14] This function fights both cancer and viral infection. If either of those things cause a cell to start making abnormal or foreign proteins then the cell is instructed to kill itself (lysis) or tagged to be destroyed by other immune cells. [15]
[11] https://biology.oer.hawaii.edu/biology171/chapter/ribosomes-and-protein-synthesis/
[12] In addition to their structural and regulatory roles in the assembly of the ribosome, RPs perform other “moonlighting” extra-ribosomal functions including the regulation of cell growth, proliferation and differentiation, immune signaling, DNA repair and apoptosis. https://www.nature.com/articles/s41392-021-00728-8
[13] In a healthy person, these exported T-cells move continuously between lymph nodes and the blood, testing APCs for signs of infection. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5091071/
[14] But when an individual develops an infection, and antigens from this infection begin to be displayed on APCs that are scanned by T-cells. [...] CD8+ T-cells may kill infected cells directly, and CD4+ T-cells help to make antibodies; both send out signals to attract macrophages and neutrophils to the site of the infection. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5091071/
[15] Cell lysis or cellular disruption is a method in which the outer boundary or cell membrane is broken down or destroyed in order to release inter-cellular materials such as DNA, RNA, protein or organelles from a cell. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6190294/
Natural Killer (NK) Cells are lymphocytes in the same family as T and B cells [...] While on patrol NK cells constantly contact other cells. Whether or not the NK cell kills these cells depends on a balance of signals from activating receptors and inhibitory receptors on the NK cell surface. Once the decision is made to kill, the NK cell releases cytotoxic granules containing perforin and granzymes, which leads to lysis of the target cell.
https://www.immunology.org/public-information/bitesized-immunology/cells/natural-killer-cells
------------ Part IV
Up until now in human history you could only end up with antigenic (things which set off an immune response) molecules displayed to the immune system on subsets of cells. Either a virus infected your cells and that virus could only attach and enter a tiny number of overall cells in your body (like SARS-CoV-2 and cells which display ACE2) or you could get cancer (which is essentially one cell over and over and over.)
Outside of that, antigenic molecules would be immediately destroyed by natural killer cells or would be collected through lymph and processed and displayed by dendritic cells in lymph tissue (nodes mostly).
These dendritic cells look like massive tree root systems and all they do is process foreign material and display it on Major Histocompatibility Complex [MHC] [16]. That's the molecule complex that acts as the "signs at city limits" announcing what's going on inside a cell to the outside world. It is the sign security (the immune system) monitors to know if there is an issue inside, as security is a cell itself, and can't enter another cell.
The immune system is blind to the intracellular environment besides these signs (MHC). One type of T-Cell, T-Helper Cells [17], move up and down the "root system" of the dendritic cell, just looking at all the signs. In this way, your lymph nodes and spleen (where this process mostly happens) act as security checkpoints, eventually coming across fragments of anything that ends up in your body. If they find something wrong, they induce an immune response to that thing which will eventually reach wherever the molecules they saw came from.
[16] The MHC controls how the immune system detects and responds to specific antigens. Antigen specificity of T-cell recognition is controlled by MHC molecules with different antigen presentation between MHC class I and class II molecules. https://www.news-medical.net/life-sciences/Functions-of-MHC-in-the-Immune-System.aspx
[17] Helper T cells are arguably the most important cells in adaptive immunity, as they are required for almost all adaptive immune responses. They not only help activate B cells to secrete antibodies and macrophages to destroy ingested microbes, but they also help activate cytotoxic T cells to kill infected target cells. https://www.ncbi.nlm.nih.gov/books/NBK26827/
------------ Part V
Back to what we are doing by injecting these lipid-soluble mRNA particles into peoples bodies;
littering them throughout all tissue, dependent on each individuals weight, lipid %, hydration, cardiovascular state, anatomy, etc. Wherever concentrations of these end up you have random cells which will start to produce altered spike proteins and display them on their signs.
The immune system notices this and starts attacking those areas. As each mRNA vaccinated cell is destroyed they spill their contents of altered spike protein (cytotoxic itself [18]) into the local area. The vaccine makers know the path to immune activation is through MHC (signs), and don't really address or care about all the excess spike protein being made. The want the sign to say "altered spike protein" but in the background factories (ribosomes) are churning out actual spike protein into the inside of the cell. This is how virus reproduce as well; once infected more viral particles are constructed inside a cell, but they don't get release to go infect other cells until the infected cell is destroyed and they can escape.
[18] Detrimental or destructive to cells. https://medical-dictionary.thefreedictionary.com/cytotoxic
more in comments...
------------ Part VI
Once these signs are made they are permanent, sort of, this is where the analogy breaks down.
All the atoms in your body are replaced about once a decade. Even your bones are constantly re-structured by osteoclasts and osteoblasts, so every 10 years you have entirely different atoms making up those bones. Even cells that generally don't replicate or die until you do like neurons and muscle (muscle cells themselves get bigger when you work out, mostly, you don't get new muscle cells although nothing is ever 100%) constantly replace their constituent parts. [19]
The MHC displaying the product the factories are making will stay embedded in the cell wall until that section of the membrane is replaced due to other natural process (e.g. endocytosis. [20]) This means that people who end up with persistent neurological or cardiac side effects may have them for years, until most of the signs stating the cell is making spike protein are torn down. For neurons in the brain, that could be years, not to mention the fact that in the mean time, the immune system is actively trying to kill off any of those cells, often successfully.
[19] It turns out that each body part has its own very distinct lifespan. The lining of the stomach, constantly under assault by digestive acid, is renewed every few days. But bones are refreshed once a decade. And there are a few parts of you that stay with you from birth to death. https://www.npr.org/sections/health-shots/2016/06/28/483732115/how-old-is-your-body-really?t=1638123734880
[20] Endocytosis is a process where cells ingest material from outside the cell by enclosing it with a portion of their cell membrane and bringing it into the cell in a membrane-bound vesicle. https://www.newworldencyclopedia.org/entry/Endocytosis
------------ Part VII
Humanity did this blindly. There is so much we don't understand about this.
A gigantic portion of your genome is dedicated to MHC. We don't have any idea about the mechanisms we are playing with. Not only are large swaths of MHC black boxes but the whole question of Clonal Selection (how your body 'knows' what is you and what isn't you, and therefore what to attack) is an open question. [21]
There are no longitudinal studies on any of this, the safety data is non-existent beyond "it probably doesn't kill many of you in the first 90 days."
Bankers, Government, and Corporations saw the opportunity to make hundreds of billions of dollars, and quickly grabbed whatever was on the shelf, dusted it off, and rushed it to market. [22]
It's one of the reasons that massive and rapid distribution is key. Not knowing what would happen, it was and is imperative to get as many doses injected as possible. While careful, isolated, controlled, longitudinal studies would easily recognize collective negative effects, even though the specifics differed, uncontrolled mass distribution during phase 4 study will make it easy to mask.
Investigating any specific, like myocarditis, will only ever bring up a low level signal that's easily dismissed "COVID causes myocarditis too!" The collective information provided by all the signals would tell a different story. The VAERs database provides the strongest signal, but is easily ignored by propagandists due to its unverified nature. It will take years to collect the data and produce irrefutable results, which is why the normal process is around 6 years from a working product. Without control groups, even that data will be easy to skew in interpretation though.
[21] Clonal selection is a theory that attempts to explain why lymphocytes are able to respond to so many different types of antigens. T and B cells are able to respond to nearly all of the world’s wide variety of antigens upon presentation. Clonal selection assumes that lymphocytes are selected during antigen presentation because they already have receptors for that antigen. https://jackwestin.com/resources/mcat-content/immune-system/clonal-selection
[22] Moderna's Covid-19 vaccine was designed in just two days https://edition.cnn.com/world/live-news/coronavirus-pandemic-11-30-20-intl/h_e33ae1918c88b1167f7f858cd728ae10
------------ Part VIII
These vaccines also have no hope of imparting robust long term immunity, and are effectively short term antibody therapy to one specific part of one specific strain.You need to have a broad spectrum of antigenic sites to induce robust and long lasting immunity. That's why vaccines are more complicated than re-producing a single bacterial protein and rubbing it on a cut. Although doing that with whiole dead bacteria (scabs) is where we saw inoculation first work.
Whether the vaccines were attenuated, destroyed, or dead, the only vaccines we have ever seen impart robust and long lasting immunity provided the whole host of antigenic particles found in the wild.
It's another reason why mRNA wasn't in widespread use in addition to the technical problem of a protective coating or encapsulation. They just don't work very well and are not vaccines. Mild endogenous antibody therapy would be a better description, which is why they had to change the definition of vaccine...
------------ Part IX
So here is where we stand.
I'm not going to bother vaguely asserting some education, position of authority, or access to unavailable information. On the contrary, anyone who reads this will see I know what I'm talking about.
I tried my best to both use proper technical terminology so all this can be easily researched, but to bridge the technical gap so a lay person could understand the mechanism behind the vaccine dangers.
By their nature, these mRNA vaccines will only ever produce widespread, diffuse and low level specific signals. Every time anyone brings up a specific side effect they won't get anywhere and the MSM will always have the fallback of "basically the same as without the vaccine but having COVID."
What about the risk before? Remember that time no one is allowed to talk about? When you could just say things like "myocarditis is nearly unheard of in children." I hope this helps someone explain to a loved one and win them over. As more and more shots are mandated to keep "antibody levels" high (since when are you supposed to walk around with high antibody levels? That's a sign of infection, not immunity, antibody levels should fade quickly and be replaced with primed memory cells), people lose their jobs, and anyone speaking out is silenced, people will have questions.
Wow, I fucked up the numbering, char count was shorter than I eyeballed. Autists will mad.
The Medicare data covers 18% of the population and is verifiable to the individual level. Why are we only allowed to see VAERS? If anything VAERS only reports 1% of the data, but can be assumed to be true due to the time it takes to fill out a form (upwards of 40 minutes). Most hospitals are too understaffed to do that. With Insurance companies they are more motivated, however, because there is a payout at the end. Therefore those stats are not only more verifiable, but accurate. Arguably the Medicare data should be made public, because the scheme was announced as for the public good.
They haven't made the data public because it is a) embarrassing, i.e. there is widespread death and injury AFTER the vaccine has been administered, but the patient has not had the 14-days-to-reach-immunity stage, and is therefore counted as 'unvaccinated' by the published numbers. b) the verifiability has privacy issues in publication. c) Medicare acts as a Public Private Partnership. When it comes to data they claim private status and keep it to themselves.