I expect you're right about it not having been done on an organism-wide scale, at least for an adult organism. I recall reading about the Chinese doing it to embryos- that's certainly the low-hanging fruit. It can certainly be delivered to the cells via lipid nanoparticles (a la covid vax), electroporation, or viral plasmid vectors. Achieving 100% penetrance in an adult organism seems like a bridge way too far at this stage, though. The complexity involved in delivering any therapeutic to every single cell in the body is mind-boggling. A few injections in the deltoid ain't gonna cut it.
You are completely correct that there is no known gene therapy at this point for adults. Crispr is simply too inaccurate to be used effectively for this, besides the delivery difficulties (it's good, but you need to have 100% precision and accuracy when you're messing with genes).
I can't recommend your comment enough. Such things need to be shouted from the hills. People going around talking like this is some gene-engineering experiment are simply misinformed (absent some alien technology), and it makes us look dumb. There are plenty of reasons to hate the vaccine- for me it's all about government overreach and turning us into compliant little lemmings. But turning us into GMOs is not one of them.
I expect you're right about it not having been done on an organism-wide scale, at least for an adult organism. I recall reading about the Chinese doing it to embryos- that's certainly the low-hanging fruit. It can certainly be delivered to the cells via lipid nanoparticles (a la covid vax), electroporation, or viral plasmid vectors. Achieving 100% penetrance in an adult organism seems like a bridge way too far at this stage, though. The complexity involved in delivering any therapeutic to every single cell in the body is mind-boggling. A few injections in the deltoid ain't gonna cut it.
You are completely correct that there is no known gene therapy at this point for adults. Crispr is simply too inaccurate to be used effectively for this, besides the delivery difficulties (it's good, but you need to have 100% precision and accuracy when you're messing with genes).
I can't recommend your comment enough. Such things need to be shouted from the hills. People going around talking like this is some gene-engineering experiment are simply misinformed (absent some alien technology), and it makes us look dumb. There are plenty of reasons to hate the vaccine- for me it's all about government overreach and turning us into compliant little lemmings. But turning us into GMOs is not one of them.