I've taken it (horse paste) monthly (at a minimum) starting in December of 21. I also take it within the week before and the week after any medical appointment, as I am distrustful of hospital/clinic/office contamination. In that time I've had three major surgeries (two knee replacements and on incision and drainage on the replacement that became infected). I do take the vitamins and minerals that have been identified for the immune system, along with others that I feel are helpful in healing from the surgeries. I've not been ill at all since I started on Ivermectin. I think this is the longest period in my adult life I've not been ill. Good stuff imo!