In a landmark decision, a Missouri jury has ordered Bayer AG's Monsanto unit to pay more than $1.5 billion in damages to three former users of its Roundup weedkiller. This ruling, one of Monsanto's largest trial losses in the five-year litigation over the herbicide, raises new questions about the safety of the controversial product and the company's future legal challenges.

In a late Friday decision, jurors awarded James Draeger, Valorie Gunther, and Dan Anderson $61.1 million in actual damages and a staggering $500 million each in punitive damages. They claimed that years of using Roundup on their properties led to their non-Hodgkin’s lymphomas. This verdict is one of the largest against a US corporate defendant this year, eclipsing even a significant $1.78 billion verdict in a federal real estate case (which could balloon to more than $5 billion), Bloomberg reports.