If it truly does spread across the world, I think it would be worth remembering the first bowl in Revelation

Revelation 16 1

Then I heard a loud voice from the temple saying to the seven angels, "Go, pour out the seven bowls of God's wrath on the earth." The first angel went and poured out his bowl on the land, and ugly and painful sores broke out on the people who had the mark of the beast and worshiped his image.