“ The safety profile of nucleoside-modified synthetic mRNA (hereafter, nms-mRNA) is far from completely understood. Trials to evaluate the biodistribution, cellular uptake, endosomal escape, translation rates, functional half-life and inactivation kinetics of synthetic mRNA, rates and duration of vaccine-induced antigen expression in different cell types, as well as potential interactions with the host genome were bypassed.”
“ The safety profile of nucleoside-modified synthetic mRNA (hereafter, nms-mRNA) is far from completely understood. Trials to evaluate the biodistribution, cellular uptake, endosomal escape, translation rates, functional half-life and inactivation kinetics of synthetic mRNA, rates and duration of vaccine-induced antigen expression in different cell types, as well as potential interactions with the host genome were bypassed.”