What’s wrong with Kathy Griffin’s face?
(twitter.com)
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They might not be (entirely) natural. Celebrities often have work done to keep up appearances in their prime (face lift, botox, etc).
I've seen 40 year olds look 80, and my parents (nearly 80 themselves) look about 60.
Smoking, poor diet, hydration, sun, exercise, skin care, all factor in how a person is going to age. There is no set way.