She was married to Gavin Newsome for crying out loud. And she hasn't aged gracefully. I just don't get it.
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Depends on the woman. Generally speaking, pre-menopause can start as early as late 30s. Most start late 40s, and few hold off until early 50s.
There are other reasons, but that's the main one that's going to cause lack of interest due to hormonal changes.