I've also taken supplements for over thirty years, and the only one that made an almost immediate difference was B1 (Thiamin). I had extreme pain from the Sciatic nerve. I couldn't walk for more than five minutes without having to stop until it subsided. I tried Chiropractic, and though it didn't help with pain, it make me more limber and just generally made me feel better. B1 though worked in about three days. I'd had the pain for five years and it was amazing to have it gone. I take 100 mg daily and I'm still pain free.