For those that want more clinical information, here is a quick write up I did on it.
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Intracellular Pathways Influenced by Ivermectin
Inhibition of the Wnt/β-Catenin Signaling Pathway: The Wnt/β-catenin pathway plays a critical role in cell proliferation and differentiation. Aberrant activation of this pathway is associated with various cancers. Ivermectin has been shown to inhibit this pathway, leading to reduced tumor growth and metastasis.
Modulation of mTOR Pathway: The mammalian target of rapamycin (mTOR) is a key regulator of cell growth and metabolism. Ivermectin can inhibit the mTOR pathway, which is often overactive in cancer cells, thereby reducing cell proliferation and promoting apoptosis.
Induction of Autophagy and Apoptosis: Ivermectin can induce autophagy, a process where cells degrade and recycle their components. This autophagic response can lead to apoptosis, particularly in cancer cells, where cellular stress and damage are prevalent. By promoting cell death in this manner, ivermectin can effectively reduce cancer cell viability.
Inhibition of Glycolysis
Cancer cells often rely on glycolysis for energy production, a phenomenon known as the Warburg effect. Ivermectin has been shown to interfere with glycolysis by:
Targeting Key Glycolytic Enzymes: Ivermectin can inhibit enzymes involved in the glycolytic pathway, such as hexokinase and phosphofructokinase. By disrupting these enzymes, ivermectin impairs the energy production of cancer cells, making it difficult for them to sustain rapid growth.
Downregulation of Glucose Transporters: Ivermectin has been observed to reduce the expression of glucose transporters (GLUTs) on the cell surface. This reduction limits glucose uptake, further restricting the glycolytic capacity of cancer cells and leading to energy depletion.
Overcoming Chemoresistance: Inhibition of P-glycoprotein (P-gp) Pumps
Chemoresistance is a significant challenge in cancer treatment, often mediated by P-glycoprotein (P-gp) pumps. These pumps actively expel chemotherapeutic agents from cancer cells, reducing their efficacy. Ivermectin's ability to inhibit P-gp pumps is crucial for overcoming this resistance:
Direct Inhibition of P-gp Activity: Ivermectin directly interacts with P-gp, reducing its drug efflux capacity. This inhibition allows chemotherapeutic agents to remain inside the cells at therapeutic concentrations, enhancing their cytotoxic effects.
Restoration of Drug Sensitivity: By inhibiting P-gp, ivermectin can restore sensitivity to previously resistant cancer drugs. This property is particularly valuable in cases where cancer cells have developed resistance to multiple drugs, often a result of overexpression of P-gp.
Synergistic Effects with Chemotherapeutic Agents: Ivermectin has been shown to work synergistically with certain chemotherapeutic agents, such as doxorubicin and vincristine, enhancing their efficacy by preventing drug expulsion from cancer cells. This combination therapy approach could lead to more effective treatment regimens with potentially lower doses of chemotherapeutic agents, reducing toxicity and side effects.
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Questions?
if you want more information on this topic, phytochemicals, their pharmacokinetic properties, other intracellular routes of cancer etc. Or you just want some research on a particular subject around medicine done, Just let me know, I would be happy to help.
Great information here. Thanks!
I have a bit of a different question:
I have a friend who years ago was addicted to meth, developed hepatitis C and then cleared it through acupuncture and other natural methods.
Double vaccinated.
Got sick about 2 years ago and was told that the hepatitis C was back.
Refused the poison that would ‘clear’ it. Now is in liver failure. And being told that a transplant is the only option. Which is a long shot considering their general health.
So these questions:
Could the recent hep C finding be a cross reaction with vax?
Is liver damage possibly related to the vax?
Are there natural remedies that can reverse the liver failure?
Many thanks for any information.
Yes, individuals with chronic liver diseases like hepatitis C (HCV) might have an altered immune response, which could theoretically make them more vulnerable to certain adverse events from any vaccine
There have been reports of cases where individuals developed hepatitis after receiving the COVID-19 vaccine. Data from the Vaccine Adverse Event Reporting System (VAERS), shows a number of cases were reported following the COVID-19 vaccine between December 2020 and March 2022.
Yes. But first I do reccomend taking DAAs.
Direct-acting antivirals (DAAs) for hepatitis C (HCV) are generally well-tolerated, with fewer side effects than older treatments like interferon and ribavirin. They also have a 95% success rate at clearing HCV.
He can choose to taking the phytochemicals alongside the DAAs or just one or the other. It's up to him in the end.
1. Phytochemicals and Their Mechanisms
1.1. Epigallocatechin Gallate (EGCG)
Mechanisms in Combatting HCV:
Inhibits HCV NS3/4A protease and NS5B polymerase.
Suppresses viral replication.
Mechanisms in Reversing Liver Damage:
Reduces oxidative stress.
Inhibits liver fibrosis by targeting fibrotic pathways.
1.2. Curcumin
Mechanisms in Combatting HCV:
Inhibits HCV NS3/4A protease.
Modulates host immune response.
Mechanisms in Reversing Liver Damage:
Reduces inflammation by suppressing pro-inflammatory cytokines.
Protects against oxidative damage.
Prevents liver fibrosis by inhibiting hepatic stellate cell activation.
1.3. Quercetin
Mechanisms in Combatting HCV:
Interferes with HCV replication.
Affects cellular pathways involved in the viral life cycle.
Mechanisms in Reversing Liver Damage:
Reduces oxidative stress.
Alleviates inflammation in the liver.
1.4. Silibinin / Silymarin
Mechanisms in Combatting HCV:
Inhibits viral replication by targeting viral proteins.
Mechanisms in Reversing Liver Damage:
Reduces oxidative stress.
Prevents liver fibrosis by blocking hepatic stellate cell activation.
Enhances liver regeneration.
1.5. Resveratrol
Mechanisms in Combatting HCV:
Inhibits HCV replication by interfering with viral protein synthesis.
Mechanisms in Reversing Liver Damage:
Reduces inflammation and fibrosis by modulating key signaling pathways.
Acts as an antioxidant to protect liver cells from damage.
1.6. Glycyrrhizin
Mechanisms in Combatting HCV:
Modulates immune response to reduce viral replication.
Mechanisms in Reversing Liver Damage:
Reduces inflammation and protects liver cells from damage.
1.7. Andrographolide
Mechanisms in Combatting HCV:
Inhibits viral replication and reduces inflammation.
Mechanisms in Reversing Liver Damage:
Reduces liver fibrosis.
Protects against oxidative stress and liver damage.
1.8. Phyllanthus amarus
Mechanisms in Combatting HCV:
Exhibits antiviral activity by blocking viral replication.
Mechanisms in Reversing Liver Damage:
Reduces liver inflammation and improves liver function.
1.9. Luteolin
Mechanisms in Combatting HCV:
Inhibits viral replication and affects related cellular pathways.
Mechanisms in Reversing Liver Damage:
Reduces inflammation and oxidative stress.
Prevents liver fibrosis.
1.10. Berberine
Mechanisms in Combatting HCV:
Interferes with viral replication and reduces inflammation.
Mechanisms in Reversing Liver Damage:
Reduces oxidative stress and inflammation.
Prevents liver fibrosis and improves liver function.
Bioavailability Issues with Phytochemicals
Phytochemicals, despite their potential health benefits, often face significant challenges with bioavailability, which can limit their effectiveness in therapeutic applications. Bioavailability refers to the extent and rate at which the active ingredient or active moiety of a drug or supplement is absorbed and becomes available at the site of action. Here are typical issues of bioavailability associated with phytochemicals:
Poor Solubility:
Many phytochemicals are lipophilic (fat-loving) and poorly soluble in water. This limits their absorption in the gastrointestinal tract where the environment is predominantly aqueous.
Low Absorption Efficiency:
Even when phytochemicals are absorbed into the bloodstream, their ability to cross cellular membranes and reach systemic circulation can be limited. This is due to their large molecular size, poor permeability, or rapid metabolism.
First-Pass Metabolism:
Phytochemicals can be extensively metabolized by the liver and gut before reaching systemic circulation. This first-pass metabolism can significantly reduce their bioavailability.
Rapid Excretion:
Some phytochemicals are rapidly excreted from the body, reducing their time to exert therapeutic effects. This rapid clearance can be due to renal excretion or metabolism by the liver.
Instability:
Phytochemicals can be unstable and degrade quickly when exposed to environmental factors such as light, heat, and oxygen. This instability can further reduce their bioavailability.
Interaction with Food and Drugs:
Phytochemicals can interact with dietary components or medications, affecting their absorption and metabolism. For example, certain foods can inhibit or enhance the absorption of specific phytochemicals.
Liposomal and Nano Formulations for Enhancing Bioavailability
Liposomal and nano formulations are advanced delivery systems designed to overcome these bioavailability issues and enhance the therapeutic efficacy of phytochemicals.
1. Liposomal Formulations
Structure and Function:
Liposomes are spherical vesicles composed of phospholipid bilayers that encapsulate phytochemicals. This lipid-based structure enhances the solubility of lipophilic compounds in an aqueous environment.
Enhanced Absorption:
Liposomes can fuse with cell membranes, facilitating the direct delivery of encapsulated phytochemicals into cells. This improves absorption and bioavailability.
Protection from Degradation:
Liposomes protect phytochemicals from degradation by encapsulating them in a lipid shell, which shields the active ingredients from environmental factors such as oxygen and light.
Reduced First-Pass Metabolism:
Liposomal formulations can bypass some of the metabolic processes in the liver and gut, reducing first-pass metabolism and increasing the amount of phytochemical reaching systemic circulation.
2. Nano Formulations
Structure and Function:
Nanoparticles are ultrafine particles with diameters in the nanometer range that can encapsulate or bind phytochemicals. They are designed to improve the solubility and stability of these compounds.
Improved Cellular Uptake:
Nanoparticles can penetrate cellular membranes more effectively due to their small size. They can deliver phytochemicals directly into cells, enhancing their therapeutic effects.
Controlled Release:
Nano formulations can provide controlled and sustained release of phytochemicals, which helps in maintaining therapeutic levels over extended periods and reduces the frequency of dosing.
Enhanced Stability:
The encapsulation of phytochemicals in nanoparticles can protect them from degradation and extend their shelf life. This stability is crucial for maintaining the efficacy of the active compounds.
Targeted Delivery:
Nanoparticles can be engineered to target specific tissues or cells, improving the precision of delivery and reducing potential side effects. This targeting can enhance the therapeutic efficacy.
Suppliments to avoid
Piperine this is in a lot of supplements be careful.
Kava
Pennyroyal Oil
Comfrey
Black Cohosh
Chaparral
Skullcap
Valerian
Aloe Vera
Links to highly bioavailable supplements
I don't recommend taking all of these at once, If i had to choose it would be:
Quercetin, Resveratrol, EGCG, Curcumin.
Nano Curcumin:https://a.co/d/dxAqEPHDo not take in excess. Excessive curcumin may inhibit certain liver enzymes, leading to an accumulation of substances the liver typically detoxifies.
Liposomal EGCG:https://a.co/d/3vJ2VzADo not take in excess. High doses have been associated with liver toxicity and liver injury.
Thanks for the information. I'll pass it on. Pretty sure the carnivore suggestion will fall on deaf ears. My friend is a vegetarian that won't consider anything else.
That's fine, have them then possibly go on a modified "Low FODMAP" diet. In the end avoid highly processed foods, only shop on the outer edges of grocery stores, avoid seed oils.
For those that want more clinical information, here is a quick write up I did on it.
------------‐---------------
Intracellular Pathways Influenced by Ivermectin
Inhibition of Glycolysis
Cancer cells often rely on glycolysis for energy production, a phenomenon known as the Warburg effect. Ivermectin has been shown to interfere with glycolysis by:
Overcoming Chemoresistance: Inhibition of P-glycoprotein (P-gp) Pumps
Chemoresistance is a significant challenge in cancer treatment, often mediated by P-glycoprotein (P-gp) pumps. These pumps actively expel chemotherapeutic agents from cancer cells, reducing their efficacy. Ivermectin's ability to inhibit P-gp pumps is crucial for overcoming this resistance:
----‐----------------
Questions?
Great information here. Thanks! I have a bit of a different question: I have a friend who years ago was addicted to meth, developed hepatitis C and then cleared it through acupuncture and other natural methods. Double vaccinated. Got sick about 2 years ago and was told that the hepatitis C was back. Refused the poison that would ‘clear’ it. Now is in liver failure. And being told that a transplant is the only option. Which is a long shot considering their general health. So these questions:
He can choose to taking the phytochemicals alongside the DAAs or just one or the other. It's up to him in the end.
1. Phytochemicals and Their Mechanisms
1.1. Epigallocatechin Gallate (EGCG)
1.2. Curcumin
1.3. Quercetin
1.4. Silibinin / Silymarin
1.5. Resveratrol
1.6. Glycyrrhizin
1.7. Andrographolide
1.8. Phyllanthus amarus
1.9. Luteolin
1.10. Berberine
Bioavailability Issues with Phytochemicals
Phytochemicals, despite their potential health benefits, often face significant challenges with bioavailability, which can limit their effectiveness in therapeutic applications. Bioavailability refers to the extent and rate at which the active ingredient or active moiety of a drug or supplement is absorbed and becomes available at the site of action. Here are typical issues of bioavailability associated with phytochemicals:
Poor Solubility:
Low Absorption Efficiency:
First-Pass Metabolism:
Rapid Excretion:
Instability:
Interaction with Food and Drugs:
Liposomal and Nano Formulations for Enhancing Bioavailability
Liposomal and nano formulations are advanced delivery systems designed to overcome these bioavailability issues and enhance the therapeutic efficacy of phytochemicals.
1. Liposomal Formulations
Structure and Function:
Enhanced Absorption:
Protection from Degradation:
Reduced First-Pass Metabolism:
2. Nano Formulations
Structure and Function:
Improved Cellular Uptake:
Controlled Release:
Enhanced Stability:
Targeted Delivery:
Suppliments to avoid
Links to highly bioavailable supplements
I don't recommend taking all of these at once, If i had to choose it would be: Quercetin, Resveratrol, EGCG, Curcumin.
Nano Curcumin: https://a.co/d/dxAqEPH Do not take in excess. Excessive curcumin may inhibit certain liver enzymes, leading to an accumulation of substances the liver typically detoxifies.
Liposomal EGCG: https://a.co/d/3vJ2VzA Do not take in excess. High doses have been associated with liver toxicity and liver injury.
Nano Quercetin: https://a.co/d/6C81D9k
Nano Silymarin: https://a.co/d/fyQuxJn
Nano Resveratrol: https://a.co/d/912GOvN
Nano Andrographis: https://a.co/d/iXVpmuY
Liposomal Luteolin: https://a.co/d/bcFdOh0
Nano Berberine: https://a.co/d/2mkZgmh
Lifestyle Changes
Wow. How do you do that so fast?
Thanks for the information. I'll pass it on. Pretty sure the carnivore suggestion will fall on deaf ears. My friend is a vegetarian that won't consider anything else.