Oxfendazole, a major metabolite of fenbendazole, is well tolerated in humans. A randomized, double-blind, placebo-controlled, phase I study conducted in 70 healthy participants evaluated multiple ascending oral doses of oxfendazole, from 0.5 to 60 mg/kg. The dose study found acceptable safety and tolerability profiles, even after 5 repeated daily doses of up to 15 mg/kg. This clinical trial also characterized the disposition of fenbendazole, describing the drug as a one-compartment model with formation rate-limited elimination

https://ar.iiarjournals.org/content/44/9/3725