Another mechanism by which the COVID-19 vaccines can lead to a systemic weakening of the immune system
👉🏻 https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1336906/full
An "out-of-sequence stimulation" is triggered.
"... these data suggest that the inflammatory environment created by the LNPs is detrimental to naïve T cells."
"... the observed changes were likely systemic since the direct draining organs, the skin-draining lymph nodes, and the distant spleen showed similar trends."
"These data align with our previous findings that exposure to mRNA-LNP or LNP leads to systemic inhibition of adaptive immune responses."
"... it exposes the adaptive immune cells to an out-of-sequence stimulation, which might worsen upon further exposure."
"Activation and differentiation of T cells into effector cells are thought to rely on three signals received from antigen-presenting cells (APCs), such as dendritic cells (DCs). The first signal is in the form of peptide-MHC, the second signal is membrane-bound co-stimulation, and the third signal is in the form of soluble cytokines. If the T cells receive the third signal before the first one, it is called out-of-sequence stimulation, which can lead to the T cells’ death or render them anergic and non-responsive (136, 137). Exposure to mRNA-LNP or LNP leads to a rapid release of inflammatory cytokines (12), including type I interferons (7) that are known to induce out-of-sequence stimulation, which likely exposes the adaptive immune cells, including the T cells, to an inflammatory environment before the mRNA is translated into protein and presented on DCs. Thus, with a high likelihood, one of the potential flaws of the mRNA-LNP platform, unlike the old-school vaccines where the antigen presentation and inflammation coincide, is that it exposes the adaptive immune cells to an out-of-sequence stimulation, which might worsen upon further exposure."
👉🏻 https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1336906/full
COVID-19 mRNA vaccines are associated with higher incidence of adverse events compared to other vaccines
👉🏻 https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1336906/full
Increased risk of ischemic stroke within 1-42 days after the coadministration of the Pfizer-BioNTech bivalent COVID-19 vaccine and influenza vaccine
👉🏻 https://publichealth.jmir.org/2024/1/e53807
"The potential association between bivalent vaccination and ischemic stroke in the 1-42–day analysis warrants further investigation among individuals younger than 65 years with influenza vaccine coadministration and prior SARS-CoV-2 infection. Furthermore, the findings on ischemic stroke risk after bivalent COVID-19 vaccination underscore the need to evaluate monovalent COVID-19 vaccine safety during the 2023-2024 season."
Neuro-Sjögren's syndrome (SS) in a 34-year-old woman 9 months after she received her third dose of COVID-19 vaccination
SS: an autoimmune chronic inflammatory disease causing peripheral nerve system and central nervous system issues.
"The present case report is about a 34-year-old woman who presented with progressive numbness, difficulty in walking, and blurred vision following the COVID-19 vaccine booster, but she never had COVID-19 or any infection."
"This case highlights the need for increased vigilance and research into vaccine-induced autoimmunity."
Will we all soon be indirectly vaccinated by eating meat?
In France, a self-amplifying mRNA vaccine is now being used in the factory farming of ducks. Helene Banoun (@BanounHelene) has published an important article on the subject:
👉🏻 https://tinyurl.com/285hwx6u
"The CEVA vaccine is a self-amplifying mRNA encoding H5 of H5N8 coated in ferric nanoparticles, and contains squalene (suspected of toxicity in humans)."
"When ducks are vaccinated with CEVA's self-amplifying mRNA product, it must be emphasized that no tests have been carried out on the ability of this gene product to be transmitted to the duck meat consumer."