If Q is asking about something unusual in our DNA, I would say that two of our chromosomes were fused together (creating the big one). That change would require taking off 4 telomeres from the ends of strands, fusing the strands together and extracting a centromere which holds the strands in an X shape. The odds of all those mutations occurring like that without any other interference are staggeringly remote. It looks to me like we were tinkered with. We are still fundamentally God's creation.