Frens, I wanted to provide an update on high blood pressure that I have been suffering from since getting COVID in early 2022. Immediately after recovering from COVID, I noticed my blood pressure and exercise tolerance were severely diminished. After going to the doctor, I was put on a light dose of Telmisartan with average BP of 150/100. The Telmisartan got me down to the upper 130s, but obviously wasn't going to fix whatever was causing my high BP. I started doing a Ketogenic / Carnivore diet. I also resolved to lose weight, and I took vitamin d3 / k2 and did the Pauling protocol off an on for close to a year. This got my blood pressure down to about 145/95 without Telmisartan, but I still couldn't exercise very rigorously without a pounding headache. I resolved to continue trying to find ways to lower my BP. Last Fall, I did research on Nitric Oxide deficiency and its effect on blood vessel health. In the course of that research, I found Dr. Nathan Bryan's N1O1 Exogenous nitric oxide lozenges that generate nitric oxide in your mouth as you let the tablet dissolve. I received my first bottle in late November 2025. Immediately after taking the first lozenge, I could feel my entire stomach and blood vessels throughout my body open up. It was actually uncomfortable as all heck! After about 5 hours, the first lozenge wore off. I was taking 3 lozenges per day, 8 hours apart. That first night, I checked my BP, and after taking my third lozenge, my BP was 135/82. Better, but still not where it needed to be. Fast forward about a week, and my BP in the evening was now dropping into the mid 120s. At this point, I started taking glutathione and NAC to increase the half life of nitric oxide in my body. After another month, I was able to drop down to 2 lozenges per day. In late April, my blood pressure was staying in the upper 120s at its highest during the day, and i could really ramp up the exercise again. By mid June, my resting BP started dropping into the 115/72 range and at this point, I dropped down to one lozenge before bed. Since then, I have been cycling 10 miles on average per day again, and feel like I am 20 years younger. I haven't as much as has a cold since I started this regimen and can work out like a beast again. It is possible to get back to 120/80. It took me years to reverse mine naturally. I just wanted to share this story, as I feel so much younger! Edit: I have added a link to a video of Dr. Bryan being interviewed about the subject. Very deep and fascinating. https://youtu.be/OgkMm0cmvMU Link for the lozenges per request. https://n1o1.com/product/n1o1-nitric-oxide-lozenges/
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Where did you get the lozenges from? Is there a protocol that you were following to know when to reduce the number of doses and when? How did you know when to add glutathione and NAC?
Thanks for the info? :-)
I got the lozenges from N1O1.com that is his retail store. The lozenges are literally called N1O1. I could initially feel the lozenge wearing off as the vessels in various parts of my body would go through a state of discomfort as the lozenge wore off. As you vessels stay expanded for longer, the effect subsided for me. After a few months, I only felt the pressure change in my ears when the lozenge was wearing off. Dr. Bryan cites clinical studies that show in a healthy person (with good hemoglobin and glutathione levels) that the lozenge should last 8 hours. After that, your endogenous NO production is all you have. I started taking glutathione because it specifically improves the half life of the nitric oxide. I took NAC because my blood and hair analysis showed I was horribly deficient in Cysteine, which is a glutathione precursor. Once I started NAC / glutathione, my blood pressure improved much faster. Until my glutathione and cysteine levels improved, the lozenges wouldnt last 8 hours before I had symptoms of higher BP returning. I take glutathione and NAC on an empty stomach several hours between meals for optimal absorption. Here is a link to a video Dr. Bryan did on the subject. https://youtu.be/OgkMm0cmvMU
Thank you so much for this. I’ll take a look! God Bless!
Spike (from covid or Vax ) binds to Ace 2 receptors on vessels and heart. This raises BP.
Nitric oxide is primarily about lowering diastolic BP.
Systolic can be high due to imbalance of Na / K. Not enough potassium makes your kidneys hold sodium (& H2O). Potassium salt and Beet powder can provide similar results as you have achieve (both cheap & easy). But after increasing potassium you may need more Na. to maintain balance.
Interesting. Mine has been similar since I got Covid.
I took Entresto (Ace 2 inhibitor) for 1 1/2 years then weaned myself.
Spike (from covid or Vax ) binds to Ace 2 receptors on vessels and heart. This raises BP.
Nitric oxide is primarily about lowering diastolic BP.
Systolic can be high due to imbalance of Na / K. Not enough potassium makes your kidneys hold sodium (& H2O). Potassium salt and Beet powder can provide similar results as you have achieve (both cheap & easy). But after increasing potassium you may need more Na. to maintain balance.
Tonight with no meds 118/67 pulse 65 75 years old (2 years ago 150/93 )
Yeah, it really got my endothelial function out of whack. The N1O1 lozenge is the only thing that ever fixed it for me. I feel 25 again, and I am 45. I also linked a video above if you are interested in watching a podcast on the subject.
Thanks. I’ll definitely check it out. Been doing ketogenic for 3 years now. Carnivore for a bot thinking that would help but didn’t. I do have abs now and my testosterone has almost doubled so I’ll stay with it. If this works I’m buying you a tomahawk ribeye.
Thanks, fren. I have been keto / carnivore most of the time for the past 2.5 years. It definitely dropped my.inflammation, but my BP just didnt go down much. I learned from Dr. Bryan's podcasts that my eNOS enzymes were decoupled. His lozenges slowly fixed mine. My blood pressure stays low all day now on just 1 lozenge! Keep me updated on your progress! Also as a side note, I started growing small hairs all over my scalp in my male pattern baldness from the lozenges too! I didn't have that on my bingo card! I started doing a few carb days now that I am cycling again. Otherwise my quads fatigue a bit quick on the hills.
Sweet! Thanks
I didn't find the product on the website. Can you link it here? Thank you for this post and the updates!
Yes, fren. Here you go https://n1o1.com/product/n1o1-nitric-oxide-lozenges/
Thank you so much!!
You're welcome. Keep me updated on your progress! Looking forward to hearing "Wow, my blood pressure os down 10 points in a week!" 😁
Will do!!
CONGRATULATIONS ON THE SUCCESSFUL JOURNEY!!!
Thank you! Finding my fountain of youth had some other positive side effects. My back doesn't hurt nearly as much anymore. I sleep like a baby. I recover faster. My joints aren't stiff in the morning. My IBS symptoms got 90% better in one week! The manhood works better too! My body was truly nitric oxide deficient!