We do over vaccinate our pets. My last one was diagnosed with osteosarcoma at age 9.5. Very late stage, too late to do anything. Many clues led up to that, the lameness, and pigmentation loss on her nose and the pink lips which was also a sign of auto immune disorder. Her parents are still living: Sire age 16 and mother age 13 and very healthy. They only received their puppy shots and a rabies each year to keep the sheriff off their lawn.

I did everything I thought was right, good food, lots of exercise and whatever shots the vet recommended. My heart still aches for that lovely girl.

The new puppy received her puppy shots, but no more except rabies. "Most" diseases that our pets come down with can be treated at home. Test for heartworm in the spring and possibly end of summer. Titer testing to see if puppy shots are still effective. All of this is expensive, my vet will still love me :) and hopefully have a healthy dog for at least 15 years.

Lots of research I continue to do.

I'm not sure how to post articles, but here are 2 I found helpful.

https://news.wisc.edu/schultz-dog-vaccines-may-not-be-necessary/

https://mypetnutritionist.com/post/vaccinosis-damage-vaccinations-can-cause-your-pet/

I know this is my first post, so sorry to bust in like this. :/

A quick google on DNA repressors. Q: What is the role of a DNA repressor? A: Gene regulation. I'm not a biologist, a scientist or any-ist. Maybe someone smarter than I can explain that?