If Someone injected Any substance that was just taken out of -70 temps then Injected into a body with a 98 degree temperature I would believe that would cause Immediate toxic shock to that body & would likely kill it? Really how long would Any of us last if we entered a freezer set at -70 with just street clothes on even for a minute? It Never made any sense regarding these vaccines as temperature changes occur when shipping frozen foods from the lower 48 to us here in Ak. There is no way it would be possible to keep these vaccines at -70 consistently & even if they could have you seen Any nurse administrating these vaccines with the appropriate gloves necessary to handle them safely-Answer-No!