Ideally, once you believe a medicine is safe you absolutely have to do a trial on children before making a recommendation to all children. Your only other alternative is to extrapolate how a medicine/dosage would work, and that has not worked out well in the past, so now the recommendation has changed to allow medical trials on children before a medicine is used on ALL children. Again, this is in logical world where something is really believed to be safe and you're not expecting problems, not clown world.