Not certain, but my guess is right when Trump called it out as a treatment. Didn't really hear much about it before then. I've known about quinine for years, since at least 2004. I was given mefloquin for southern Iraq. I researched what it was and where it came from. It was the strongest anti-malarial that we had at the time. Bad side effects. Quinine is what started it all, before that malaria was responsible for more human deaths than everything else combined. I think it still might be.