Each notch = 50lbs. I weigh 183 so I took the equivalent of 3 notches. I could have used 4 notches because weight wise I'm in the middle of a notch but I felt 3 maybe a little safer. I've seen some people say as high as 6 notches but I wasnt trying to use anymore than necessary.

On the durvet brand they have it broken down in 250 lb increments and then that 250 is broken down by 5 notches.

There is a lock collar (not necessary) but it prevents you from pushing out too much.

To be honest I was more worried about the weight than milligrams. I had brain fog and vertigo that wouldnt go away for almost 3 weeks. Took my first dose in the late evening and it started going away in an hour. Next morning I felt great with those symptoms completely gone.

Disclaimer: I'm not a doctor and am not giving anyone medical advice. What worked for me may not be safe or work for you.