I know what this would take and don’t believe what you are saying.

I worded my statement poorly, my apologies. What I meant to say was, if I had isolates from the wild of all the variants, I could get a reasonable determination of the virulence and transmission of what they are calling "variants". I can't do the same thing with a virus I create from an RNA sequence (or buy) because that is not necessarily a wild type virus. I am taking their word for it, which I am very hesitant to do at this point.

As for experimenting on humans, I can use human cell lines (or even in situ experiments) to get a reasonable determination. Its not perfect, but its at least a reasonable experiment that would give bounds on the data that is being presented.

Nevertheless, your objection is valid. I couldn't use such variants on humans to get real good data.

This might pass for some but not for me you are a total crank.

That's just rude. There is no reason to go there. If you have an objection raise it. You did and it was valid. I responded with respect. There is zero reason you can't do the same.