Change my mind
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The Argentines have been using Ivermectin prophylactically and in treatment since May/June 2020. It was so widespread there that I remember seeing an article in either Smithsonian or Scientific American saying they couldn’t find control subjects in those countries because everyone was already on it.
They developed the IDEA protocol—made from medications widely available in almost all countries because of their designation as WHO essential medications. Cut mortality in their ICUs from 28% to 3%, and only one person in the first study on it had reportable side effects.