PEG is probably being used as a linker molecule. I'm guessing it's what links the RNA part to the lipid part. It's not like they just pour antifreeze into the vial. It's a chemical part of the biologic I bet. That being said I have in fact heard people at my company talking about how PEG linkers are the cause of toxicity when these drugs are tested in primates. At the last place I was working at they were trying to find a replacement linker because the poor mice kept having seizures.
I'm copying from another forum on this topic:
PEG is probably being used as a linker molecule. I'm guessing it's what links the RNA part to the lipid part. It's not like they just pour antifreeze into the vial. It's a chemical part of the biologic I bet. That being said I have in fact heard people at my company talking about how PEG linkers are the cause of toxicity when these drugs are tested in primates. At the last place I was working at they were trying to find a replacement linker because the poor mice kept having seizures.
Yeah, the "chemical found in yoga mats" thing for Subway really impacted how this sort of thing is told.