Was very interested to read that citrus fruits also contain hesperidine, considering there have been a few posts here already about homemade quinine or HCQ recipes from citrus, such as:
https://greatawakening.win/p/13zg4u1Grg/homemade-hydroxychloroquine-ques/
https://greatawakening.win/p/12kFrp1pwG/grapefruit-quinine-/
Hesperidine was listed in following website as potentially effective against covid from docking studies (prevent spike protein docking in Ace2:
8 Potential Anti-COVID Compounds Revealed by Molecular Docking Studies, lists natural compounds that are surfacing with promising anti-coronavirus activity (from studies) and includes:
- quercetin
- Epigallocatechin gallate (EGCG)
- Curcumin
- hesperidin
https://www.drkarafitzgerald.com/2020/04/17/8-potential-natural-anti-avoid-compounds/
Based on recent computational and experimental studies, hesperidin, a bioactive flavonoid abundant in citrus peel, stands out for its high binding affinity to the main cellular receptors of SARS-CoV-2, outperforming drugs already recommended for clinical trials. Thus, it is very promising for prophylaxis and treatment of COVID-19, along with other coexistent flavonoids such as naringin, which could help restraining the pro-inflammatory overreaction of the immune system.
https://www.preprints.org/manuscript/202003.0214/v1
Hesperidin, rhoifolin, pectolinarin, and cannabinoids had about the same pose as nelfinavir, but were better than chloroquine and hydroxychloroquine sulfate as Mpro inhibitors. These plant compounds have the potential to be developed as specific therapeutic agents against COVID-19.
https://www.preprints.org/manuscript/202004.0152/v1
So this may give you another reason to get simmering those grapefruit/citrus.
I hadn't actually read that other post, and was looking at a paper linked by another post here when I saw about hesperidin, then looked into it further and saw it was citrus related, then wondered if the other posts about extracting quinine from grapefruit, might also be extracting hesperedin, so giving a double whammy effect.