In regards to “subzero” temperatures, that is entirely dependent upon the stability of the IND. you usually don’t freeze attenuated viruses anyways, because you’d fucking kill it. Sauce For mRNA, you’re gonna have to rely on the manufacturers’ stability and validation protocols.
In case you’re disagreeing; https://clinicaltrials.gov/ct2/show/NCT04848584
In regards to “subzero” temperatures, that is entirely dependent upon the stability of the IND. you usually don’t freeze attenuated viruses anyways, because you’d fucking kill it. Sauce For mRNA, you’re gonna have to rely on the manufacturers’ stability and validation protocols.