My horse is borderline diabetic and has been taking ivm (either the paste or the pills, whichever I can procure) prophylactically for several months now. No ill effects whatsoever. In fact, my horse is more likely to feel "on top of the world" the day after than anything else. i can tell by the spring in his trot! Of course, if your horse actually has parasites, his/her body will react by feeling ill for a while because of the die-off. I searched several topics (with yahoo, not googs) using either ivermectin or hydroxychloroquine combined with such terms as diabetes, autoimmune disease, cancer, etc. and pulled up a lot of scientific papers. i've done this on two evenings and was completely gobb-smacked each time. And I do mean gobb-smacked. Each seems to help with sugar regulation/diabetes, help with/cure some cancers, either on its own or synergistically with other treatments, etc, etc and seems to be a miracle drug. hcq (excuse TMI) blocked my horse up completely, so I no longer give it to him. I ordered it because it is still supposed to be the standard for prophylactic use, but ivm seems like it's made for my horse. Have also tried fenbendazole (canine form, panacur), which is supposed to help with cancer, on my horse, and plan on a course of it for pre-cancerous changes shortly. Zero ill effects from that either. These anti-helminthics seem to do it all. No experience with or research on type 1, but fear not for type 2. It will cure what ails your horse!