This study, to best of our knowledge, was the first to provide ivermectin‐regulated virus‐related pathways by SILAC quantitative proteomics analysis, which revealed a broad‐spectrum antiviral property of ivermectin. More exciting thing was that the identified ivermectin‐regulated proteins included some reported SARS‐CoV‐2‐related proteins, and it could assist in exploiting potential ivermectin‐related biomarkers and the novel mechanisms in the treatment of SARS‐CoV‐2 infection. The combination of ivermectin with other drugs might result in more favorable prognoses for patients with COVID‐19. For example, one study hypothesized that the combination of hydroxychloroquine and ivermectin might show a consequential and synergistic action for treatment of COVID‐19 (Patrì & Fabbrocini, 2020). We anticipate our results to guide efforts to understand the molecular mechanisms underlying ivermectin used for the treatment of SARS‐CoV‐2 infection. Furthermore, our findings provide insight into the development of ivermectin as an option for the treatment of COVID‐19 in the context of PPPM research and practice.
Viruses such as human cytomegalovirus (HCMV), human papillomavirus (HPV), Epstein–Barr virus (EBV), human immunodeficiency virus (HIV), and coronavirus (severe acute respiratory syndrome coronavirus 2 [SARS‐CoV‐2])
These findings demonstrate the broad‐spectrum antiviral property of ivermectin benefiting for COVID‐19 treatment in the context of predictive, preventive, and personalized medicine in virus‐related diseases.
5. CONCLUSION
This study, to best of our knowledge, was the first to provide ivermectin‐regulated virus‐related pathways by SILAC quantitative proteomics analysis, which revealed a broad‐spectrum antiviral property of ivermectin. More exciting thing was that the identified ivermectin‐regulated proteins included some reported SARS‐CoV‐2‐related proteins, and it could assist in exploiting potential ivermectin‐related biomarkers and the novel mechanisms in the treatment of SARS‐CoV‐2 infection. The combination of ivermectin with other drugs might result in more favorable prognoses for patients with COVID‐19. For example, one study hypothesized that the combination of hydroxychloroquine and ivermectin might show a consequential and synergistic action for treatment of COVID‐19 (Patrì & Fabbrocini, 2020). We anticipate our results to guide efforts to understand the molecular mechanisms underlying ivermectin used for the treatment of SARS‐CoV‐2 infection. Furthermore, our findings provide insight into the development of ivermectin as an option for the treatment of COVID‐19 in the context of PPPM research and practice.
Viruses such as human cytomegalovirus (HCMV), human papillomavirus (HPV), Epstein–Barr virus (EBV), human immunodeficiency virus (HIV), and coronavirus (severe acute respiratory syndrome coronavirus 2 [SARS‐CoV‐2])
Hmm....
And from the Abstract: