Transmission of TSEs from infected individuals is relatively rare. TSEs cannot be transmitted through the air or through touching or most other forms of casual contact.
However, they may be transmitted through contact with infected tissue, body fluids, or contaminated medical instruments. Normal sterilization procedures such as boiling or irradiating materials do not prevent transmission of TSEs.
TSEs tend to progress rapidly and usually culminate in death over the course of a few months to a few years.
There is currently no treatment that can halt progression of any of the TSEs. Treatment is aimed at alleviating symptoms and making the patient as comfortable as possible. A clinical trial of a potential therapy for CJD is expected to begin soon at the University of California at San Francisco.
Symptoms of TSEs vary, but they commonly include personality changes, psychiatric problems such as depression, lack of coordination, and/or an unsteady gait. Patients also may experience involuntary jerking movements called myoclonus, unusual sensations, insomnia, confusion, or memory problems. In the later stages of the disease, patients have severe mental impairment and lose the ability to move or speak.
The E-64d cysteine protease inhibitor was generously provided by S. Ishiura, Tokyo University, Tokyo, Japan.
**Quinacrine and chloroquine were obtained from Sigma. **
Amphotericin B (Fungizone) was purchased from Bristol-Myers Squibb (Tokyo, Japan).
The sodium salt of PPS (Cartrophen Vet) was purchased from Biopharm (Bondi Junction, New South Wales, Australia) and used after removal of an alcohol additive by drying.
E-64d was dissolved in dimethyl sulfoxide, amphotericin B was dissolved in distilled water, and all other chemicals were dissolved in phosphate-buffered saline (PBS).
University of California, San Francisco
San Francisco, California, United States
Transmission of TSEs from infected individuals is relatively rare. TSEs cannot be transmitted through the air or through touching or most other forms of casual contact.
However, they may be transmitted through contact with infected tissue, body fluids, or contaminated medical instruments. Normal sterilization procedures such as boiling or irradiating materials do not prevent transmission of TSEs.
TSEs tend to progress rapidly and usually culminate in death over the course of a few months to a few years.
There is currently no treatment that can halt progression of any of the TSEs. Treatment is aimed at alleviating symptoms and making the patient as comfortable as possible. A clinical trial of a potential therapy for CJD is expected to begin soon at the University of California at San Francisco.
Symptoms of TSEs vary, but they commonly include personality changes, psychiatric problems such as depression, lack of coordination, and/or an unsteady gait. Patients also may experience involuntary jerking movements called myoclonus, unusual sensations, insomnia, confusion, or memory problems. In the later stages of the disease, patients have severe mental impairment and lose the ability to move or speak.
https://www.ninds.nih.gov/Disorders/All-Disorders/Transmissible-Spongiform-Encephalopathies-Information-Page
Has Results CJD (Creutzfeldt-Jakob Disease) Quinacrine Study
** Drug: Quinacrine**
https://clinicaltrials.gov/search/term=Transmissible%20Spongiform%20Encephalopathies
Treatment of Transmissible Spongiform Encephalopathy by Intraventricular Drug Infusion in Animal Models https://www.ncbi.nlm.nih.gov/pmc/articles/PMC400350/
Chemicals.
The E-64d cysteine protease inhibitor was generously provided by S. Ishiura, Tokyo University, Tokyo, Japan.
**Quinacrine and chloroquine were obtained from Sigma. **
Amphotericin B (Fungizone) was purchased from Bristol-Myers Squibb (Tokyo, Japan).
The sodium salt of PPS (Cartrophen Vet) was purchased from Biopharm (Bondi Junction, New South Wales, Australia) and used after removal of an alcohol additive by drying.
E-64d was dissolved in dimethyl sulfoxide, amphotericin B was dissolved in distilled water, and all other chemicals were dissolved in phosphate-buffered saline (PBS).
HOPE THIS HELPS SOMEONE