I have had migraine (with vertigo, but they don’t always happen at same time) for over 15 yrs, and been recently diagnosed with Meniere’s.
My neurologist prescribed Ajovy injection for me about a year ago, I stopped taking it after a few months because the price skyrocketed from $5 to over $700. That’s when all the stuff about what’s in the vaxx started coming out. About a month ago I went back for my follow appointment and told him about the price change. So he was able to prescribe it for me for $5 again at the pharmacy. It’s a once a month injection. But now because of what’s in the vaxx, I’m worried about the contents of this medicine, so still have not taken it.
Does anyone have any thoughts about this medicine?
Here is the some info on Ajovy ... Fremanezumab-VFRM ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422958/
~~Some info from this site ...
Fremanezumab-vfrm (hereafter referred to as fremanezumab) [AJOVY™] is a fully humanized monoclonal antibody (IgG2Δa) developed by Teva Pharmaceuticals to selectively target calcitonin gene-related peptide (a vasodilatory neuropeptide involved in the pathophysiology of migraine). Its use has been associated with significant reductions in migraine frequency, the requirement for acute headache medication use and headache-related disability compared with placebo in multinational, phase III studies, and in September 2018 fremanezumab was approved by the US FDA for the preventive treatment of migraine in adults. A regulatory assessment for fremanezumab as a preventive treatment of migraine in adults is underway in the EU. Fremanezumab is also undergoing phase III development for the preventive treatment of cluster headache (although a phase III chronic cluster headache study has been suspended due to the results of a prespecified futility analysis) and phase II development for the preventive treatment of post-traumatic headache disorder. This article summarizes the milestones in the development of fremanezumab leading to this first approval in the USA for the preventive treatment of migraine in adults.
~~It looks like it originally came from Pfizer ...
In January 2013, Labrys Biologics acquired the worldwide rights to fremanezumab from Pfizer [8]. Under the terms of the agreement, Pfizer will be eligible to receive milestone payments and sales royalties [8]. In July 2014, Teva Pharmaceutical Industries (hereafter referred to as Teva) acquired Labrys Biologics (and the fremanezumab programme) for an upfront payment of US$200 million and contingent payments of up to US$625 million (subject to the achievement of certain development milestones) [9, 10]. In May 2017, Teva and Otsuka Pharmaceuticals (hereafter referred to as Otsuka) entered into a development and commercialization agreement [11]. Under the terms of this agreement, Otsuka acquires exclusive rights to fremanezumab and will fund clinical studies in Japan, while Teva receives a payment of US$50 million and will be eligible for milestone payments upon filing and regulatory approval in Japan and upon the achievement of revenue targets [11].
Teva is the company that has Ajovy now ...
https://www.tevapharm.com/search-results/?keywords=Fremanezumab
I think I can offer you some good, solid information and recommendations.
I have been a chronic migraine sufferer now, for about twelve years. It started from a long-term exposure to formaldehyde fumes coming from a sofa, of all things. I had it tested, sounds crazy. Long story.
Anyway, I use all kinds of triptans to help manage it, having to rotate through them because of a tolerance problem. With me, I also have an immune inflammatory response inside my skull, so when necessary, I also use low-dose doxepin as a heavy-duty antihistamine to knock the immune component back. I have also been taking Aimovig since it came out, using their $5 co-pay program. Since covid, I am becoming more and more concerned that the injection could become spiked, although Novartis and Amgen aren't involved with the vaccines.
But here's the thing. You mentioned Meniere's. Are you aware of the connection between celiac/gluten sensitivity and migraines, a whole host of other neurological symptoms, as well as Meniere's? https://www.glutenfreesociety.org/gluten-sensitivity-and-vertigomenieres-disease/ I have recently discovered I have adult-onset celiac, probably brought on by the formaldehyde exposure. Celiac doesn't necessarily manifest in gastro symptoms: https://pubmed.ncbi.nlm.nih.gov/15608953/ There are a lot of links if you search using these keywords.
What you need to do is have your doctor write you labs for celiac DNA, as well as gliadin antibodies. You can only have the antibody test, as well as the biopsy, performed while you are consuming gluten. Otherwise, if you go gluten-free, these tests will come up negative even though you might be positive. The difference between celiac gastro and celiac neuro is the recovery time. Gastro patients can start noticing improvement within six weeks or so of going gluten-free. Neuro patients may require two years.
This is just a summary of what you should know. I can provide more information if you like. Best wishes.
Thank you! I am reading on it now. I will call my doctor next week and ask about it. Can’t believe neither my neurologist or ENT never considered this? I go to my neurologist for migraines & ENT for Meniere’s. Just found out that my ENT retired without offering his patients options for a new doctor. So now I have to find a new ENT to treat my Meniere’s.