Some cancer types cannot use ketones for energy, so by keeping blood glucose very low the cancer is deprived of energy it requires.
Some cell lines lack the ketolytic enzymes 3-hydroxybu-
tyrate dehydrogenase 1 (BDH1) and succinyl-CoA: 3-oxoacid
CoA transferase 1 (OXCT1).
For example, lung cancer type H1299 lacks both of those enzymes, while lung cancer type A549 has both intact.
A person with the H1299 type could maintain high ketone levels (under careful supervision) while artificially lowering blood glucose to very low levels. This is dangerous, but if high ketone levels are maintained the person will not go into a hypoglycemic coma (this has been proven). Doing this for say 48 hours would starve the cancer of energy while leaving healthy tissue unaffected.
The journal article that researched some of this is "Low ketolytic enzyme levels in tumors predict ketogenic
diet responses in cancer cell lines in vitro and in vivo" or you can find it on sci-hub.
Some cancer types cannot use ketones for energy, so by keeping blood glucose very low the cancer is deprived of energy it requires.
Some cell lines lack the ketolytic enzymes 3-hydroxybu- tyrate dehydrogenase 1 (BDH1) and succinyl-CoA: 3-oxoacid CoA transferase 1 (OXCT1).
For example, lung cancer type H1299 lacks both of those enzymes, while lung cancer type A549 has both intact. A person with the H1299 type could maintain high ketone levels (under careful supervision) while artificially lowering blood glucose to very low levels. This is dangerous, but if high ketone levels are maintained the person will not go into a hypoglycemic coma (this has been proven). Doing this for say 48 hours would starve the cancer of energy while leaving healthy tissue unaffected.
The journal article that researched some of this is "Low ketolytic enzyme levels in tumors predict ketogenic diet responses in cancer cell lines in vitro and in vivo" or you can find it on sci-hub.
This stuff is so amazing!