Safety of oral ivermectin during pregnancy: a systematic review and meta-analysis Published JANUARY 01, 2020
https://www.thelancet.com/journals/langlo/article/PIIS2214-109X(19)30453-X/fulltext
Before Covid or Ivermectin was a political issue it was shown as safe for pregnant women at normal doses and safe for others at at least 10x recommended dose
"This study was sponsored by a grant from Merck Research Laboratories, a division ofMerck & Co., Inc"
https://pubmed.ncbi.nlm.nih.gov/12362927/
Download full PDF study from webarchive
https://web.archive.org/web/20210719231037/https://sci-hub.st/10.1177/009127002237994
"Ivermectin was generally well tolerated, with no indication of associated CNS toxicity for doses up to 10 times the highest FDA‐approved dose of 200 μg/kg.
All dose regimens had a mydriatic effect similar to placebo.
Adverse experiences were similar between ivermectin and placebo and did not increase with dose."
Journal of Clinical Pharmacology, 2002;42:1122-1133 ©2002 the American College of Clinical Pharmacology
"This study demonstrated that ivermectin is generally well tolerated at these higher doses and more frequent regimens."
"In summary, the safety profile generated in this study supports the use of oral ivermectin at the approved dose levels and at dose levels being considered for the treatment of head lice. Furthermore, a significant safety margin is demonstrated. However, studies in the pediatric population are necessary to confirm safety in children at higher dose levels.
The pharmacokinetic parameters are consistent with those previously established, with the exception of a slightly longer half-life. A significant food interaction was demonstrated.
We would like to acknowledge the following individuals for their considerable contributions to this study:
Mr. Manuel Pinto and the staff of Clinical Pharmacology Associates for their invaluable help with study conduct and patient recruitment,
Ms. Geraldine Bolden of Merck Research Laboratories for her excellent work in conducting the image analysis of the pupillometry transparencies,
Ms. Mitra Asgary of Merck Research Laboratories for her contribution in analyzing the pharmacokinetic samples, and
Dr. Stephanie Larouche, formerly of Merck Research Laboratories, for her encouragement and scientific guidance."
https://sci-hub.st/https://doi.org/10.1177/009127002237994
here are the author affiliations:
From Merck Research Laboratories, Blue Bell and West Point, Pennsylva-nia, and Terlings Park, United Kingdom (Dr. Guzzo, Ms. Furtek, Dr. Porras,Dr. Chen, Mr. Tipping, Ms. Clineschmidt, Dr. Sciberras, Dr. Hsieh) andClinical Pharmacology Associates, Miami, Florida (Dr. Lasseter).
This study was sponsored by a grant from Merck Research Laboratories, a division ofMerck & Co., Inc.
Dr. Lasseter has no financial interest in Merck & Co. Dr. Sciberras was employed by Merck & Co., Inc., at the time of the study. All other authors are currently employed by Merck & Co., Inc.
Submitted for publication March 5, 2002; revised version accepted June 30, 2002.
Ad-dress for reprints: Ms. Christine Furtek, Merck & Co., Inc., BLX-29, P.O. Box4, West Point, PA 19486.
Yes but lets ask for a justification of the censorship and what was wrong with the published trials
Either they did not do their job or they were were withholding safety information when false claims were made by Merck, others and the FDA about Ivermectin being dangerous
Grounds to show they cannot do their job or are involved in a fraud or misrepresentation by deliberately withholding info the public is entitled to be made aware of and knowingly making claims that high doses of ivermectin cause death or serious issues.
No research I have found shows any deaths or serious long term harm caused by ivermectin in humans.
I believe some people have taken huge doses of ivermectin by mistake
That is mal administration for which they are accountable
Ivermectin as Cancer Treatment FDA web site trial
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7505114/
2017 Nature Magazine
Many successful Ivermectin Trials for many serious viruses and serious diseases like cancer
https://www.nature.com/articles/ja201711
View web archive link below for other links and comments including webarchive links to data on deleted and censored data posts and info on ivermectin
See posts and info on Ivermectin since 2020
https://web.archive.org/web/20210904141313/https://forums.livescience.com/threads/ivermectin-has-been-shown-very-effective-against-covid-19-infections-why-is-no-one-talking-about-it.3278/
The FDA set out about Ivermectin is dangerous and provided no trial evidence that Ivermectin is dangerous or that the Merck Trials showing Ivermectin was very safe at at least 10x times FDA doses were false or flawed.
No such effects were reported in the Merck ivermectin trials yet the FDA stated
"You can also overdose on ivermectin, which can cause nausea, vomiting, diarrhea, hypotension (low blood pressure), allergic reactions (itching and hives), dizziness, ataxia (problems with balance), seizures, coma and even death."
https://www.fda.gov/consumers/consumer-updates/why-you-should-not-use-ivermectin-treat-or-prevent-covid-19
Studies linking ivermectin with human deaths or side effects are hard to find and were either peer reviewed and shown as misleading or deaths were linked to cases where very high levels of parasites treated by ivermectin were present
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8087035/
Ivermectin has been used extensively and has been associated with a low frequency of side-effects.5 Barkwell and Shields' conclusion that ivermectin should not be used for treatment of scabies in elderly patients is not supported by our results.
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(05)62377-X/fulltext
Wow! All the responses to this posting. I'm grateful to you all for this information.